Complexes antitumor activity

Salts of neodecanoic acid have been used in the preparation of supported catalysts, such as silver neodecanoate for the preparation of ethylene oxide catalysts (119), and the nickel soap in the preparation of a hydrogenation catalyst (120). Metal neodecanoates, such as magnesium, lead, calcium, and zinc, are used to improve the adherence of plasticized poly(vinyl butyral) sheet to safety glass in car windshields (121). Platinum complexes using neodecanoic acid have been studied for antitumor activity (122). Neodecanoic acid and its esters are used in cosmetics as emoUients, emulsifiers, and solubilizers (77,123,124). Zinc or copper salts of neoacids are used as preservatives for wood (125). 

Gibberellic acid (Figure 16) complexes of [Bu2Sn(IV)] , [BusSnflV)], and [PhsSndV)] have been prepared. The monomeric [BusSndV)]" derivative has the strongest antitumor activity. ... 

Finally, more and more experimental data must be collected in order to understand the biological (including antitumor) activity of organotin(IV) complexes... 

Table 6.4 Cytotoxcitiy and antitumor activity of selected gold complexes on B16 Melanocytes and P388 leukocyte. Adapted from Shaw [17].

Shaw, C.F. Ill, Beery, A. and Stocco, G.C. (1986) Antitumor activity of two binudear gold(I) complexes with bridging dithiolate ligands. Inorganica Chimica Acta, 123, 213-216. 

Mirabelli, C.K., Johnson, R.K. and Hdl, D.T. (1986) Correlation of the in vitro cytotoxic and in vivo antitumor activities of gold(I) coordination complexes./oumal of Medicinal Chemistry, 29, 218-223. 

McKeage, M.J., Maharaj, L. and Berners-Price, S.J. (2002) Mechanisms of cytotoxicity and antitumor activity of gold(I) phosphine complexes the possible role of mitochondria. Coordination Chemistry Reviews, 232, 127—135. 

An iron(III) complex of 2-acetylpyridine 3-azabicyclononylthiosemi-carbazone, 4, the thiosemicarbazone that was found to have the most potent antimalarial activity of a large number of 2-acetylpyridine thiosemicarbazones tested [88], was originally formulated as 5-coordinate [Fe(4-H)Cl2], [135], but more recent studies have shown it to be [Fe(4-H)2] [FeCl4] [117]. This complex has similar antimalarial activity to that of the uncomplexed ligand, but possesses enhanced antitumor activity [136]. 

Formylisoquinoline S-methyldithiocarbazate, 19, forms green [Cu(19-H)Cl], and its magnetic moment of 1.80 B.M. and v(d-d) = 16000 cm are cited as evidence for planar stereochemistry [146]. It and the analogous zine complex showed the greatest antitumor activity of metal eomplexes tested. 

The electronic spectra and magnetic susceptibility of [Ni(21)Cl2] were found to be consistent with a five-coordinate high spin complex. This complex has greater antitumor activity against P388 lymphocytic leukemia test system in mice than cobalt(II), copper(II), zinc(II) and platinum(II) complexes of 21 [187],... 

The in vitro trypanocidal and antitumor activities of lfr(cot)L], cot = cyclotetraene, derivatives of dithiocarbamates and xanthates, have been investigated.700 The Ir complexes were characterized by IR spectroscopy, and MO calculations (Hiickel) were performed on the ligands. Similar studies were performed on [Ir(nbr)L], nbr = norbornadiene, L = derivatives of alquil and aryl xanthates 701 and also on [Ir2(cod)2L]X2, where L = 2-hydroxystilbamidine, X = C1, N03, C104, BPh4, and [Ir(cod)L2 ]X, where L = benznidazole, R0-2516, nifurtimox, niridazole. The complex [Ir2(cod)2(2-hydroxystilbami-dine)](BPh4)2 showed the highest activity, as studied by optical microscopy of rats kidneys. 

Colquhoun and Schumacher [98] have shown that y-linolcnic acid and eicosapentaenoic acid, which inhibit Walker tumor growth in vivo, decreased proliferation and apoptotic index in these cells. Development of apoptosis was characterized by the enhancement of the formation of reactive oxygen species and products of lipid peroxidation and was accompanied by a decrease in the activities of mitochondrial complexes I, III, and IV, and the release of cytochrome c and caspase 3-like activation of DNA fragmentation. Earlier, a similar apoptotic mechanism of antitumor activity has been shown for the flavonoid quercetin [99], Kamp et al. [100] suggested that the asbestos-induced apoptosis in alveolar epithelial cells was mediated by iron-derived oxygen species, although authors did not hypothesize about the nature of these species (hydroxyl radicals, hydrogen peroxide, or iron complexes ). 

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