Stability and Compatibility

N.J. Blay I. Duns tan, USNatTechlnform-Serv, AD 744871 (1970) CA 78, 6069 (1973) Compatibility and stability problems encountered in the design and development of weapon systems containing expls and solid proplnts are discussed. Safety during storage and reliability in service are emphasized. The effects of materials used near or in contact with the expls and proplnts are considered... 

Compatibility and Stability Problems Associated with Pyrotechnic Progress 1970—1973 , Ref 155 61) Yu.N. Sukhushin et al, De-... 

Appropriate resources should be consulted for compatibility and stability information before mixing components (e.g., manufacturer s information, Trissel s Handbook on Injectable Drugs, and King Guide to Parenteral Admixtures). 

N.J. Blay I Dunstan, "Compatibility and Stability Testing of Explosives and Solid Propellants , US NTIS, AD Rep 1970,... 

Blay, N.J., and Dunstan, I. (1970) Compatibility and stability testing of explosives and propellants, Explosives R D Establishment, Waltham Abbey, Essex, UK, Technical Report 45. 

A detailed account of the compatibility and stability of explosives-definition, implications and effect of various parameters such as temperature of storage, chemical constitution of explosive vis-a-vis other ingredients, sunlight and electrostatic discharge etc has already been given in Chapter 1 (Section 1.4.1). In this section, the test methods used to determine compatibility and stability are discussed. 

The vacuum stability test and heat test are the most common tests used to determine the compatibility and stability of explosives with polymers or contact materials. However, an impact sensitivity test is sometimes used in order to derive additional information. 

Excipient compatibility and stability studies rely on two underlying assumptions. One is that there is no change in reaction mechanism as temperature increases the second is that the excipient is also chemically stable under the conditions of test. However, if the reaction mechanism does change with temperature, it is likely the result will show a disproportionately greater breakdown than would be anticipated from lower temperature studies. Thus the risk is that an excipient is rejected that might in reality be perfectly suitable for the formulation. In many cases this is probably an acceptable risk. 

Compatibility and Stability Problems Associated with Pyrotechnics, Progress 1970—73 , 3rd SympChemProblConnectedStabExpls (Proc), 1973, 275—84 (Publ 1974) CA 82, 142272 (1975) 41) Anon, Timing Systems... 

Approved packaging is normally selected after completing package performance qualification testing as well as product compatibility and stability studies. Since in most cases (exceptions transdermal delivery systems, diagnostic tests, and medical devices) packaging is not intimately involved in the manufacturing process of the product itself, it differs from other factors, such as raw materials. 

Other Laundry Products. Laundry boosters are bleaching systems that are added separately to the wash. They contain 10 as a brightener this compound is easy to incorporate and shows good compatibility and stability during storage [147],... 

C. Astre, Compatibility and stability of granisetron, dexametha-sone and methylprednisolone in injectable solutions, J. Pharm. Sci., 84 261 (1995). 

P.-H.C. Yuen, et al., Compatibility and stability of labetalol hydrochloride in commonly used intravenous solutions. Am. J. Hosp. Pharmacol. 40 1007-1009, 1983. 

Packaging An ideal container should protect the product from the external atmosphere such as heat, humidity, and particulates, be nonreactive with the product components, and be easy to use, light in weight, and economic [14]. As tubes made of aluminum and plastic meet most of these qualities, they are extensively used for packaging semisolids. Aluminum tubes with special internal epoxy coatings are commercially available for improving the compatibility and stability of products. Various modified plastic materials are used for making ointment tubes. Tubes made... 

Appropriate resources should be consulted for compatibility and stability... 

The oxidation products of catecholamines are often colored (quinones, adre-nochroms). However, the extent of discoloration does not truly indicate the extent of degradation. Therefore, visual inspection based on color changes is an inadequate means of assessing the compatibility and stability of catecholamines (76). Except for dobutamine, colored solutions of catecholamines should not be used. The photoprotected storage of catecholamines is imperative. 

Allwood MC. Compatibility and stability of TPN mixtures in big bags. J Clin Hosp Pharm 1984 9 181-198. 

It is important to note that only one-fourth of the drugs approved by the FDA have indications specific for use in a pediatric population. Medications used in adults are often given to children without FDA safety and efficacy data. Compatibility and stability issues with dosage forms intended for adults that have been altered (e.g., dilution or reformulation) can increase risks for ADRs. 

Johnson DM, Gu LC. Autoxidation and antioxidants. In Swarbrick J, Boylan JC, eds. Encyclopedia of Pharmaceutical Technology, volume 1. New York Marcel Dekker, 1988 415 50. Allwood MC. Compatibility and stability of TPN mixtures in big bags. / Clin Hasp Pharm 1984 9 181-198. 

The stability of soybean oil emulsions may be readily disturbed by the addition of other materials, and formulations containing soybean oil should therefore be evaluated carefully for their compatibility and stability. 

Establishment of good quality control techniques and good manufacturing practices and of facilities for formulation and packaging development activity to undertake compatibility and stability tests as well as safety testing and bioavailability studies. 

The titratable acidity or alkalinity of a system may be more important than pH itself in determining compatibility and stability. For example, an autoclaved solution of dextrose may have a pH as low as 4.0, but the titratable acidity in such an unbuffered solution is low. 

---