Colony stimulating factors G-CSF

Neutropenia is a drop in the number of circulating leukocytes, especially neutrophils. It can be induced by a variety of drugs. Treatment with cytotoxic antineo-plastic drags usually results in severe neutropenia, which can be treated with colony-stimulating factors (G-CSF, GM-CSF). 

Duarte, R. and Frank, D. 2002. The synergy between stem cell factor (SCF) and granulocyte colony stimulating factor (G-CSF) molecular basis and clinical relevance. Leukaemia and Lymphoma 43(6), 1179-1187. 

Granulocyte colony-stimulating factor (G-CSF), 5-10 mcg/kg subcutaneously once daily for 2-4 weeks or granulocytemacrophage colony-stimulating factor (GM-CSF), 250 mcgftn2 subcutaneously for 2-4 weeks (CM)... 

Interleukins (IL-l-IL-13 have now been characterised) colony-stimulating factors (CSFs), such as granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF (GM-CSF) and macrophage CSF (M-CSF) ... 

Stem cell therapy involves infusion of specialized cells utilized to perform specific functions. The traditional use of cell therapy includes harvest and cryopreservation of autologous hematopoietic cells either from the bone marrow (old approach) or mobilization and pheresis of hematopoietic stem cells from peripheral blood using stem cell-mobilizing cytokines such as hematopoietic colony-stimulating factors (G-CSF, GM-CSF) or chemokine inhibitors (AMD-3100). A more recent stem cell source is umbilical cord blood that has rich pleuripotent potential and can engraft at lower doses than bone marrow or mobilized peripheral blood stem cells. 

Keywords granulocyte colony-stimulating factor (G-CSF) LTC-IC CFU-C granulocytes... 

Mobilised peripheral blood stem cells are used as the source of stem cells for transplantation, moreover most allogeneic transplants now utilize peripheral blood rather than bone marrow A variety of mobilisation regimes are used but granulocyte colony-stimulating factor (G-CSF) is the most frequently In some cases G-CSF treatment of volunteers is involved researches ... 

Granulocyte colony-stimulating factor (G-CSF) (Neupogen 48 Mio U, F.Hoffmann-La Roche, Switzerland) was dissolved in 0,85% NaCl with 0,1% bovine serum albumin (Sigma) and was injected subcutaneously (25 pg/kg in 0,2 ml of 0,85% NaCl) once a day for 4 days. White blood cells (WBC) count and the hemogram of the peripheral blood were analyzed before and one day after each course. Seven courses were performed during half-year. 

In the next phase of the study, transcripts of up-regulated genes granulocyte colony-stimulating factor (G-CSF) and IgG were introduced into a mouse model corranonly used to test potential therapies for experimental autoimmune encephalomyelitis (EAE). Erom microarray analysis, G-CSF was found to be up-regulated in acute MS but not in the chronic state of the disease. Subcutaneous injection of G-CSF prior to induction of EAE prevented onset of the disease in mice. The reversal of EAE by G-CSE has also been described (see Eock, 2002, Reference 40). 

The feasibility and efficacy of granulocyte-colony stimulating factor (G-CSF) therapy and subsequent intracoronary infusion of collected peripheral blood stem cells were prospectively investigated in the MAGIC randomized clinical trial [137], which showed improved cardiac function and promotion of angiogenesis in myocardial infarction patients. 

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