Colon tumor targeting

Liu C, Tadayoni BM, Bourret LA, Mattocks KM, Derr SM, Widdison WC, Kedersha NL, Ariniello PD, Goldmacher VS, Lambert JM, Blattler WA, Chari RVJ (1996) Eradication of Large Colon Tumor Xenografts by Targeted Delivery of Maytansinoids. Proc Natl Acad Sci U S A 93 8618... 

One of the obvious advantages of orthotopic models is that targeting processes involved in local invasion (e.g., angiogenesis) can be undertaken at a clinically relevant site (36). Since the early studies showing orthotopic transplantation of colon tumors and metastasis to the liver (39), tumor xenografts have been grown orthotopically in mice. However, despite the clinical relevance of orthotopic models, their utilization is hindered by a need for a high level of technical skill, time and cost. Therapeutic efficacy is also more difficult to assess with orthotopic models in contrast to the relative ease of subcutis tumor measurements (36). 

In addition, antibodies to tumor markers labeled with a radioactive tag are used to localize the tumor masses (radioimmunoscintigraphy) or to provide direction for labeled antibodies to attack the tumor site. Examples are the use of radiolabeled antibodies to CEA to localize colon tumors and the application of labeled antibodies against ferritin to target hepatocellular carcinoma. This approach is... 

When treated with carcinogens, telomerase-null mice develop tumors less readily than normal mice do. For example, papillomas Induced by a combination of chemical carcinogens occur 20 times less frequently In mice lacking a functional telomerase than In normal mice. Mice with an APC mutation normally develop colon tumors, and these too are reduced If the mice lack telomerase. Some other tumors are less affected by loss of telomerase. These studies demonstrate the relevance of telomerase for unbridled cell division and make the enzyme a possible target for chemotherapy. 

Lee J H, et al. (2005). Suppression of progression and metastasis of established colon tumors in mice by intravenous delivery of short interfering RNA targeting KITENIN, a metastasis-enhancing protein. Cancer Res. 65(19) 8993-9003. 

C. Griffin, A. Kamik, J. McNulty, and S. Pandey, Pancratistatin selectively targets cancer cell mitochondria and reduces growth of human colon tumor xenografts. Mol. Cancer ner., 10 (2011) 57-68. 

Jain A, Jain SK (2008) In vitro and cell uptake studies for targeting of ligand anchored nanoparticles for colon tumors. Eur J Pharm Sci 35(5) 404-416... 

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