Collection enhancement programs

Scientists at AstraZeneca shared their experiences with their historical compound collections, which prompted them into defining a number of selection criteria in order to filter out compounds of little value for the hit-to-lead process [27]. Subsequently, this led to a compound collection enhancement program. 

In a compound collection enhancement strategy, only very few of the possible structures are eventually produced. Some companies have also generated large virtual databases based on validated reaction protocols, such as Pfizer s Q Libri with over 10 members [28]. Enamine [29], a Ukrainian provider of test compoimds, has a virtual library with 30 million compoimds based on their experience of a well-performing reaction combined with a large number of available diversity reagents, called the fiill real database.  

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X HE LEVELS OF INDUSTRIAL CHEMICAL WASTES BEING DUMPED into our nation s coastal waters are constantly being monitored by the National Oceanic and Atmospheric Administration (NO A A). To carry out the frequent marine monitoring programs necessary to stay abreast of this problem, it was determined in 1977 that more expedient shipboard sampling and analyses systems would have to be developed. One area of prime interest for sampling and scrutiny was the surficial seafloor sediments. To enhance rapid data collection, the ability to analytically measure samples while at sea was essential. This capability would allow areas of interest to be delineated and studied in detail before the survey vessel returned to port. 

This World Wide Web resource is a collection of AHRQ Supported Guidelines, AHRQ Technology Assessments and Reviews, ATIS (HIV/AIDS Technical Information), NIH Warren G. Magnuson Clinical Research Studies, NIH Consensus Development Program, Public Health Service (PHS) Guide to Clinical Preventive Services and the Substance Abuse, and Mental Health Services Administration s Center for Substance Abuse Treatment (SAMHSA/CSAT) Prevention Enhancement and Treatment Improvement Protocols. 

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