Reagent diversity

Reagent diversity is quicker to calculate than fully enumerated final product libraries. 

In reaetions with nueleophilie reagents diaeetylene behaves as aeetylene aeti-vated with aeeeptor group that is eommon to eonjugated polyynes. Therefore, the nueleophilie addition of amines, aleohols, and thiols oeeurs to its terminal position and leads to the formation of the eorresponding l-heteroalk-l-en-3-ynes readily involved in diverse eyelization reaetions. 

Over the last few years the number of heterocyclic N—F reagents has developed tremendously (Fig. 1). The driving force for this interest has been the need for easily accessible and safe reagents capable of the selective fluorination of bioactive molecules. Generated by reaction of F2 with the parent compound, products are obtained that are capable of fluorinat-ing species as diverse as carbanions and aromatics depending on their fluorinating power. 

The reaction of tert-alkyl Grignard reagents with carboxylic acid chlorides in the presence of a copper catalyst provides ieri-alkyl ketones in substantially lower yields than those reported here.4,14 The simplicity and mildness of experimental conditions and isolation procedure, the diversity of substrate structural type, and the functional group selectivity of these mixed organocuprate reagents render them very useful for conversion of carboxylic acid chlorides to the corresponding secondary and tertiary alkyl ketones.15... 

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