Collagens collagen-like proteins

Collagen is the most abundant extracellular matrix protein family in vertebrates. Proteins in the collagen superfamily all have three polypeptide chains with the required -Gly-Xaa-Yaa- repeated sequence, where Xaa and Yaa are frequently proline and 4-hydroxyproline, respectively. At present, more than 30 molecular species of vertebrate proteins called collagen are classified into 28 types as type I, II, III,..., XXVIII. They are typically called type N collagen , or collagen N . In addition, there are many more collagen-like proteins that... 

List of Known Binding Sequences in Collagens and Collagen-Like Proteins... 

Streptococcus collagen-like protein 1 and 2 BclA, Bacillus collagen-like protein in anthrax. Peptides are indicated by the notation used in Table II, or by the single letter code for the residues other than Gly-Pro-Hyp triplets. 

O-Linked Oligosaccharide from Bacillus Collagen-Like Protein of Anthracis... 

T2. Titaev, A. A., Determination of collagen-like proteins in blood serum. Lab. Delo 9, 5-7 (1963). 

The nematode cuticle consists largely of cross-linked collagen-like proteins that are secreted by the hypodermis, an anatomical syncytium that is also specialized for transport. The quasi-elastic structure of the cuticle and the high turgor... 

In addition to collagen and collagen-like proteins, nematode cuticle contains at least one glycoprotein and small amounts of hyaluronic acid and lipid. Lipid components, which are localized in the cortex of A. suum (111), have not been chemically characterized. Also present in the cuticle are chondroitin sulfate and sulfated mucopolysaccharides, which convey a negative charge to the cuticle (99). 

Chartier, A., Zaffran, S., Astier, M., Semeriva, M. Gratecos, D. (2002). Pericardin, a Drosophila type IV collagen-like protein is involved in the morphogenesis and maintenance of the heart epithelium during dorsal ectoderm closure. Development 129, 3241-3253. 

Peng, Y.Y., Yoshizumi, A., Danon, S.J., Glattauer, V., Prokopenko, O., Mirochnitchenko, O., Yu, Z., Inouye, M., Werkmeister, J.A., Brodsky, B., Ramshaw, J.A., 2010. A Streptococcus pyogenes derived collagen-like protein as a non-cytotoxic and non-immunogenic cross-linkable biomaterial. Biomaterials 31, 2755—2761. 

Although the encephalitogenic effect of brain or spinal cord homogenate had been known for many years, it was the separation of two proteins, homogeneous by ultracentri-fugational and electrophoretic criteria, that promoted further research. These were a collagen-like protein with low EAE activity [124], and a basic protein obtained by a different... 

Otolin-1 is a collagen-like protein associated with calcium carbonate in otoliths it was isolated from otoliths of the chum salmon Oncorhynchus keta. Otoliths are small pieces of calcium carbonate, mainly aragonite, located in the inner ear of vertebrates but also in many invertebrates. Very sensitive to gravity and linear acceleration, otoliths play an important role in the balance of the organism . Otoliths from Osteichthyes are constituted by layers of aragonite, the accretion rate of which varies with the age of the fish hence, by studying otoliths it is possible to determine the age of a fish (Kimura and Anderl, 2005). The structure of otolin-1 is not yet completely determined (Murayama et al., 2002, 2005). 

Resilin and elastin have relatively high extensibility and resilience, but as compared to the collagen and the silks, the proteins sacrifice stiffness (elastic modulus) and strength (see Table 2). Collagen and dragUne sflk are much stiffer materials, but lack the extensibility that is characteristic of the rubber-like proteins. On the other hand, the mussel byssus fibers and the viscid silk have the extensibility of resilin and elastin, but lack the resilience [208]. 

Sylvestre, P. Couture-Tosi, E. Mock, M. Polymorphism in the collagen-like region of the Bacillus anthracis BclA protein leads to variation in exosporium filament length. /. Bacteriol. 2003,185,1555-1563. 

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