Cognitive function in schizophrenia

Weinberger DR, Gallhoffer B Cognitive function in schizophrenia. Int Clin... 

According to this model, a discussion of potential therapeutic drug effects on cognitive function in schizophrenia should focus upon the correction of abnormalities in thought and speech. Other authors, e.g. Schultz and Andreasen (1999), appear to subsume a much wider range of schizophrenic symptoms under the umbrella of cognitive abnormalities Several cognitive and emotional functions are impaired, such as perception (hallucinations),... 

Some patients improve with ziprasidone when conventional antipsychotics fail, although probably not as much as with clozapine. Studies demonstrate that ziprasidone is highly effective for the positive symptoms and also improves the negative symptoms of schizophrenia. Some studies suggest that ziprasidone may improve cognitive functioning in schizophrenia and also in dementia. 

Kawai, N., Yamakawa, Y., Baba, A., Nemoto, K., Tachikawa, H., Hori, T., Asada, T., Iidaka, T. 2006, High-dose of multiple antipsychotics and cognitive function in schizophrenia the effect of dose-reduction, Prog.Neuropsychopharmacol. Biol.Psychiatry, vol. 30, no. 6, pp. 1009-1014. 

Cholinesterase inhibitors have been evaluated in schizophrenia as adjunctive treatments to ameliorate cognitive deficits as well as negative symptoms. O Table 1.2-2 summarizes studies on the adjunctive use of cholinesterase inhibitors for the treatment of schizophrenia. Overall, the effects of cholinesterase inhibitors on cognitive function in schizophrenia are modest (Ferreri et al., 2006). Beyond cognition, cholinesterase inhibitors also have modest effects on tardive dyskinesia (Tammenmaa et al., 2004). 

LaPorte DJ, Lahti AC, Koffel B, Tamminga CA. 1996. Absence of ketamine effects on memory and other cognitive functions in schizophrenia patients. J Psychiatr... 

Dwork AJ, Mancevski B, Rosoklija G. 2007. White matter and cognitive function in schizophrenia. Int J Neuropsycho-pharmacol 10 513-536. 

Siekmeier PJ, Hasselmo ME, Howard MW, Coyle J. 2007. Modeling of context-dependent retrieval in hippocampal region CA1 Implications for cognitive function in schizophrenia. Schizophr Res 89 177-190. 

Mortimer A (1997) Cognitive function in schizophrenia-do neuroleptics make a difference Pharmacol Biochem Behav 56 789-795. 

McGurk SR, Meltzer HY. The effects of atypical antipsychotic drugs on cognitive functioning in schizophrenia. Schizophr Res 1999 25 233-55... 

Suzuki H, Gen K. The influence of switching from oral risperidone to risperidone long-acting injection on the clinical symptoms and cognitive function in schizophrenia. Ther Adv Psychopharmacol 2012 2(l) 23-9. 

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