Cognitive abnormalities

According to this model, a discussion of potential therapeutic drug effects on cognitive function in schizophrenia should focus upon the correction of abnormalities in thought and speech. Other authors, e.g. Schultz and Andreasen (1999), appear to subsume a much wider range of schizophrenic symptoms under the umbrella of cognitive abnormalities Several cognitive and emotional functions are impaired, such as perception (hallucinations),... 

COGNITIVE ABNORMALITIES IN ATTENTION DEFICIT HYPERACTIVITY DISORDER... 

Goldberg TE, Straub RE, Callicott JH, Hariri A, Mattay VS, et al. 2006. The G72/G30 gene complex and cognitive abnormalities in schizophrenia. Neuropsychopharmacology 31 2022-2032. 

The factors associated with behavioral and cognitive abnormalities in children taking topiramate have been studied retrospectively (644). There were behavioral or cognitive abnormalities in 11 of 75 children at 2-4 months after the start of therapy. The mean dosage (4.6 mg/kg/ day) at which these abnormalities were observed was similar to the mean final dose (5.8 mg/kg/day) in children... 

Gerber PE, Hamiwka L, Connolly MB, Farrell K. Factors associated with behavioral and cognitive abnormalities in children receiving topiramate. Pediatr Neurol 2000 22(3) 200-3. 

The availability of genetically modified mice has advanced our understanding of several neurodegenerative processes. Cellular neurobiology experiments have informed us about mechanisms of neuronal dysfunction in AD and PD mouse models. For instance, recent studies have identified that synaptic transmission is one of the earliest events in the cognitive abnormalities that characterize AD and PD. The integration of this information with data-based circuits modeling, in which neuronal electrical properties, synaptic transmission parameters, and brain oscillations can now be evaluated and it has been recently addressed in PD and AD. 

Physiological adjustments take place during the gradual progression of the disorder, so that even a severe hemoglobin deficiency may produce few symptoms. Iron deficiency may affect the proper development of the central nervous system. Early childhood iron deficiency anemia may lead to cognitive abnormalities. 

When one pair of chromosomes does not divide, the resulting cells have 24 chromosomes and others have 22. A fertilized egg will develop into a child with Down syndrome, where the child inherits genes on 46 chromosomes 23 coming from the mother and 23 from the father. The extra chromosome causes physical and cognitive abnormalities, ranging from mild-to-severe learning disabilities. The symptoms are similar to those of patients with Alzheimer s disease. 

---