Codeine tablets

In 2 fatalities involving the ingestion of large numbers of codeine tablets, postmortem blood concentrations of codeine of 15 and 48 pg/ml were reported urine concentrations were 155 and 370pg/ml in both cases alcohol had also been ingested and in one case a low concentration of salicylate was also found in the blood (M. A. Peat and A. Sengupta, Forens. Sci., 1977, 9, 21-32). 

A 44-year-old black man developed priapism 2 hours after having overdosed on 30-40 trazodone tablets 50 mg and 10 Tylenol No. 3 (paracetamol plus codeine) tablets (162). Toxicology analysis was positive for cocaine and opiates. The priapism required detumescence twice, on initial presentation and then 6 hours later, and 8 hours after presentation he again developed painless priapism, which resolved spontaneously after 1.5 hours. 

Aspirin BP In fine powder form for preparation of Soluble Aspirin Tablets and Soluble Aspirin, Phenacetin and Codeine Tablets... 

Figure 4.16 Development of free salicylic acid in aspirin-paracetamol-codeine and aspirin-phenacetin-codeine tablets at37X.

Thirty minutes before the peel, the patient is given a paracetamol (acetaminophen) plus codeine tablet or any other relatively strong analgesic. The skin is cleaned (Skin Tech Pre-peel cleanser ), rinsed and dried. It is then disinfected with alcohol and degreased with acetone, which are left to evaporate. ... 

The patient can take a paracetamol (acetaminophen) plus codeine tablet half an hour before going to the doctor. The patient may also benefit from taking a second tablet 1 or 2 hours after the peel, at the peak of the discomfort. 

The eyelids and upper lip can be treated with Lip Eyelid formula, without any analgesic other than a paracetamol plus codeine tablet to be taken 1 hour before treatment. Patients should also be given a clear description of the pain they will feel. By the time they have counted to 15, the pain will have gone. 

Chapter 33 is devoted to the details of anesthesia for a phenol peel. Lip Eyelid formula can be applied without any anesthetic on small areas, however. Patients feel an intense burning sensation a few seconds after application. They will have been told that the burning sensation only lasts for 15 seconds and that they can have a nerve block if they want. Vocal anesthesia plays an important part, and the patient can take a paracetamol (acetaminophen) plus codeine tablet 1 hour before the treatment. Nerve blocks are often used to increase patient comfort 2% Hdocaine without adrenaline (epinephrine) is used, and its duration of action is sufficient. The patient should be given paracetamol plus codeine tablets for the post-peel pain, which is inevitable during the first 24 hours because of the severity and rapidity of inflammation caused by the peel. 

Normal recurrence of pain for several hours paracetamol plus codeine tablet... 

A woman weighing 135 lb takes two codeine tablets of 20 mg each as directed by her dentist to alleviate the pain associated with minor dental surgery. Assuming that the peak plasma concentration is reached in 1 hour, of codeine is 3.0 L/kg, F = 50%,... 

Many methods have appeared in the literature during recent years which depend upon chromatographic or ion-exchange separation of the ingredients. The following method has been found to be very satisfactory for routine determination of both Compound Codeine Tablets.. and Soluble Compound Codeine Tablets. 

Estimation of Other Alkaloids in Opium. Of the other alkaloids the most important is codeine, and processes for its estimation in opium have been described by Cespari, Andrews,and Annett and co-workers methods for its assay in admixture with other drugs in tablets and other products are also available. The estimation of papaverine has been described by Issekutz,i and of narcotine by Snesarov. As to methods for the separation and estimation of two or more of these subsidiary alkaloids, codeine and narcotine have been dealt with by van der Widen,narcotine and papaverine by Annett and Bose, ( and the bromination of codeine and narceine has been studied by Vaisberg et al. with a view to estimation by this means. 

Promethazaine HCl/w Codeine Cough Syrup—codeine phosphate, promethazine HC1 Quad Tann Tablets—carbetapentane tannate, chlorpheniramine tannate, phenylephrine tannate, ephedrine tannate... 

Typical examples that fall in this group would be the determination of the active ingredients in analgesic tablets for pharmaceutical use, such as aspirin or codeine or the analysis of a food product such as margarine. Examples of both these analyses will be described to illustrate the sample preparation procedure. 

In reference 68, a different approach was used to verify the robustness of a CE separation of ibuprofen, codeine phosphate, degradation products, and impurities in a drug product (tablet). Small variations around the optimal conditions obtained during method optimization were introduced and the results were predicted from the response model. The variations in the factor levels during the robustness evaluation were smaller than those evaluated during method optimization. Since both migration times and resolutions were acceptably predicted, the method was considered robust with respect to the small changes. The examined factors... 

An MEKC method for the determination of ibuprofen, codeine phosphate hemihydrate, their nine potential degradation products, and impurities in a commercial tablet formulation was developed, optimized, and fully validated according to ICH guidelines and submitted to the regulatory authorities. The optimized system containing ACN as organic modifier allowed baseline separation of ibuprofen, codeine, and nine related substances within 12 min. 

Carisoprodol/ASA/Codeine Phosphate Soma compound w/ Codeine 325/200/16 mg tablets... 

Stated content/tablet = aspirin 250 mg, paracetamol 250 mg, codeine phosphate... 

Weight of tablet powder taken for analysis = 0.1228 g Weight of t-butanol internal standard added = 8.0 mg Area of internal standard peak = 7.2 Area of aspirin CH3 peak = 5.65 Area of paracetamol CH3 peak = 6.73 Codeine phosphate CH3 peak = 0.115 MW t-butanol = 74.1 MW aspirin = 180.2 MW paracetamol = 151.2 MW codeine phosphate = 397.4 Number of protons in t-butyl group = 9... 

Number of protons in methyl groups of aspirin, paracetamol and codeine = 3. Calculation of the paracetamol in the tablets is shown in Example 8.2. 

Brontex and Guiatussin with Codeine are two brand-name cough suppressants available in tablet form. They contain 10 mg of codeine plus the expectorant guaifenesin. (An expectorant helps expel mucus secretions from the airways.)... 

Codeine, either alone or in combination with other drugs, is given orally as a tablet or capsule or in liquid form (including as syrup). Codeine can also be delivered via intramuscular injection, usually for patients unable to swallow because of a medical condition such as throat cancer. One of the interesting pharmacologic characteristics of codeine is the drug s potency... 

Tylenol with codeine acetaminophen Tablets, liquid Relief of acute pain of mild-to-moder-ate intensity... 

---