Codeine cough

Promethazaine HCl/w Codeine Cough Syrup—codeine phosphate, promethazine HC1 Quad Tann Tablets—carbetapentane tannate, chlorpheniramine tannate, phenylephrine tannate, ephedrine tannate... 

Schedule V—The drug or other substance has (1) a low potential for abuse relative to the drugs or other substances in Schedule IV, (2) a currently accepted medical use in treatment in the United States, and (3) abuse of the drug or other substance may lead to limited physical dependence or psychological dependence relative to the drugs or other substances in Schedule IV. Example codeine cough syrup. 

Dextromethorphan is an opioid antitussive similar in action to codeine and pholcodine. Codeine and pholcodine are considered to be more potent than dextromethorphan. Dextromethorphan tends to cause less constipation and dependence than codeine. Cough suppressants are not usually recommended in children under 2 years. 

Let s say that I just purchased 6 fl. oz. of average codeine cough syrup. I read the label and find that every fl. oz. contains ... 

Eccles, R. Codeine, cough and upper respiratory infection. Pulm. Pharmacol. 1996, 9, 293-297. 

Concerta see Methylphenidate Coties see Codeine Cough syrup see Codeine Cough-X see Dextromethorphan Cozmo s see PCP (phencyclidine)... 

Insom-X see GBL GHB Invigorate see GBL GHB Ionamin see Diet pills Iophen DM NR see Dextromethorphan Ischott see Catha edulis Isobutyl nitrite see Inhalants Isocarboxazid Marplan see Antidepressants Isosorbide see Diuretics Iubulu see Catha edulis J La rocha see Rohypnol La salade see Catha edulis LA turnarounds see Dextroamphetamine Lady see Heroin Lady K see Ketamine Laevoamphetamine see Amphetamines Laudanum see Opium Laughing gas see Nitrous oxide LBJ see PCP (phencyclidine) Leaky bolla see PCP (phencyclidine) Leaky leak see PCP (phencyclidine) Lean (codeine cough syrup) see Codeine... 

Most of us are aware of the big Codeine cough-syrup scare of the early 60 s. All of a sudden, with a history going back to the Civil War, we "discover" a few milder Codeine addicts are still around, and set out to stomp them out via the media. As a result, some heavy anti-cough syrup legislation was created, and millions of people became aware that Codeine existed. Abuse rate shot way up, and to this date we still have... 

Partial agonists Codeine Cough suppressant Analgesia Used in combination with NSAIDs... 

Narcotic Antitussives. Since its isolation in 1832, codeine [76-57-3] (27) has been one of the most widely used and effective compounds for the treatment of cough. Though less potent than morphine [57-27-2] (28), it has become the reference against which most antitussives are measured. 

Codeine, like morphine, is isolated from the opium poppy. However, the low yield of 0.7—2.5% does not provide sufficient material to meet commercial demands. The majority of marketed codeine is prepared by methylating the phenolic hydroxyl group of morphine. Morphine yields from opium poppy are 4—21%. When prescribed for cough, the usual oral dose is 10—20 mg, three to four times daily. At these doses, adverse side effects are very few. Although the abuse potential for codeine is relatively low, the compound can substitute for morphine in addicts (47). 

Nonnarcotic Antitussives. The most centrally active, noimarcotic antitussive is dextromethorphan [125-71-3] (39). It is similar to codeine in terms of potency and mechanism of action, ie, it is a direct depressant of the cough center. It is unique in that even though it is stmcturaHy related to codeine, it is not addictive. 

Levopropoxyphene [2338-37-6] (42), the optical antipode of the dextrorotatory analgetic propoxyphene, is an antitussive without analgetic activity. The 2-naphthalenesulfonate salt has a less unpleasant taste than the hydrochloride salt, and is widely used. Clinical effectiveness has been demonstrated against pathological and artificially induced cough, but the potency is somewhat less than codeine. The compound is reported not to cause addiction. Levopropoxyphene can be prepared (62) by first resolving [ -dimethylamino-CX-methylpropiophenone with dibenzoyl-(+)-tartaric acid. The resolved... 

Oxolamine [959-14-8] (57) is sold in Europe. It is an oxadiazole, and its general pharmacological profile is described (81). The compound possesses analgesic, antiinflammatory, local anesthetic, and antispasmodic properties, in addition to its antitussive activity. Although a central mechanism may account for some of the activity, peripheral inhibition of the cough reflex may be the dominant effect. The compound has been shown to be clinically effective, although it is less active than codeine (82,83). The synthesis of oxolamine is described (84). 

Dia2epam [439-14-5] (60) and clona2epam [1622-61 -3] (61) suppress cough induced by electrical stimulation of the lower brainstem of cats (90). Clona2epam and dia2epam adrninistered intravenously are about thirty-five times and six times more potent than codeine, respectively. Nevertheless, the compounds have not been widely used as antitussives in humans. Dia2epam is used in the treatment of anxiety, and clona2epam as an anticonvulsant. 

N. B. Eddy and co-workers. Codeine andits Alternatives For Pain and Cough Relief, World Health Organization, Geneva, Switzerland, 1970, p. 127. 

Relief of severe, persistent cough (codeine, although the drug s use has declined)... 

Use of codeine may result in respiratory depression, euphoria, light-headedness, sedation, nausea, vomiting, and hypersensitivity reactions. The more common adverse reactions associated with the antitussives are listed in the Summary Drug Table Antitussive, Mucolytic, and Expectorant Drugs. When used as directed, nonprescription cough medicines containing two or more ingredients have few adverse reactions. However, those that contain an antihistamine may cause drowsiness. 

Tricodeine Cough Cold Liquid—codeine phosphate, pyrilamine maleate... 

Morphine and related opiates are known to suppress the cough reflex these compounds have thus been used extensively in antitussive preparations. Since this activity is not directly related to the analgesic potency, the ideal agent is one that has much reduced analgesic activity and thus, presumably, lower addiction potential. The weak analgesic codeine (4) is... 

Persistent, mild cough, which may be bothersome, may be treated with dextromethorphan more severe coughs may require intermittent codeine or other similar agents. 

A formula for a cough syrup contains 1/8 gr of codeine phosphate per teaspoonful. How many grams of codeine phosphate should be used in preparing two pints of the cough syrup ... 

If a cough syrup contains 0.24 g of codeine in 120 mL, how many milligrams of codeine are contained in each teaspoonful dose ... 

In addition, morphine has served as a point of departure for the discovery of many medically usefnl derivatives. These inclnde codeine, a pain reliever and cough suppressant, levophanol, an orally active analgesic (morphine is not active when given orally and is nsnally given by injection), and many other modem and highly potent opiate analgesics. 

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