COCILLANA BARK

Common/vernacular names Cocillana bark, grape bark, guapi, trompillo, and upas. 

Trees native to the South American Andes. Part used is the dried bark. The original cocillana bark is believed to be derived from G. rusbyi. However, there is evidence that the current drug is obtained from other closely related Guarea species and is not the same as the cocillana first introduced into modem medicine (usd 23rd). The bark is collected in Haiti and Bolivia (evans). 

Chemical studies on cocillana are limited. Cocillana bark is reported to contain small amounts (0.003-0.023%) of alkaloid(s) (ras-byine) of which the chemical stmcture(s) has not been determined. It also contains P-sitos-terol, a volatile oil, tannin, anthraquinones, flavonols, terpenoids, and others (list and horhammer). ... 

Cocillana, the dried bark of Guarea rusbji (Britt.) Rusby, was probably first used by the natives of the Bolivian Andes as an emetic—cathartic. It is often prescribed as an alternative to ipecac in the treatment of cough, and the emetic side effects at high doses suggest a mechanism of action similar to that of ipecac. 

COCILLANA (Syn. Guarea, Guapi Bark) Guareae Cortex is the bark of Guarea rusbyi (Britt.), Rushy and closely related species, family Meliaceae. It is obtained mainly from Bolivia. Cocillana is a more stimulating expectorant than Ipecacuanha. The unidentified alkaloid fraction contributes most probably to the expectorant effect. 

Grape Bark Guapi bark BP Cocillana Liquid Extract (BPC 1973). 

Cocillana is the dried bark of Guarea rusbyi (Meliaceae) containing not less than 3.5% of alcohol soluble extract. 

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