Protein clusters

Reece, R.J., Ptashne, M. Determinants of binding-site specificity among yeast Ce zinc cluster proteins. Science 261 909-911, 1993. 

FIGURE 12.3 S = 9/2 EPR of Desulfovibrio desulfuricans hybrid cluster protein. Note the weak low-field peak with g > 14 and the relatively strong intensities in the g 5.4 and g 6.4 regions, which are all characteristics of the S = 9/2 system. 

Archana R, Sonali S, Deepthy M et al (2010) Molecular receptor specific, non-toxic, near-infrared emitting Au cluster-protein nanoconjugates for targeted cancer imaging. Nanotechnology 21 055103(1-12)... 

Hwang DM, Dempsey A, Tan KT, Liew CC. 1996. A modular domain of NifU, a nitrogen fixation cluster protein, is highly conserved in evolution. J Mol Evol 43 536 0. 

Li J, Kogan M, Knight SAB, et al. 1999. Yeast mitochondrial protein, Nfslp, coor-dinately regulates iron-sulfur cluster proteins, cellular iron uptake, and iron dis-tribntion. J Biol Chem 274 33025-34. 

An abbreviation for Ifigh-potential iron-sulfur protein, which is now regarded as a ferredoxin. In its role as a bacterial electron transfer component, this [4Fe-4S] cluster protein can undergo interconversion to the [4Fe-4S] and [4Fe-4S] states. 

Figure 3. Approaches to cluster protein targets for screening of small molecule libraries. Currently, protein targets are clustered based on functional or amino acid sequence similarity (left). We propose to cluster proteins purely based on structural similarity of protein cores and to apply this clustering to compound library design (right).

An interesting new tetranuclear iron hybrid cluster protein (HCP) has been observed and characterized from two sulfate reducing bacteria. Combined X-ray diffraction and EPR data showed that it contains both oxygen and sulfur bridges between the iron ions. The nature of the cluster was found to be independent of the presence or absence of oxygen in the sample preparation.247... 

PFO puruvate ferredoxin oxidoreductase, HCP hybrid cluster protein, PNO... 

PFO puruvateiferredoxin oxidoreductase, HCP hybrid cluster protein, PNO pyruvate NADH oxidoreductase, Nbp35 P-loop NTPase, Nar/Narf hydrogenase-like protein, Rli ATP-binding cassette protein... 

Hackstein JHP, Akhmanova A, Boxma B, Harhangi HR, Voncken FGJ (1999) Hydrogenosomes eukaryotic adaptations to anaerobic environments. Trends Microbiol 7 441-447 Han KL, Yong TS, Ryu JS, Hwang UW, Park SJ (2004) Identification of the hybrid cluster protein, HCP, from amitochondriate eukaryotes and its phylogenetic implications. J Microbiol Biotechnol 14 134-139... 

The ability to form a stable one-electron-reduced radical (semiquinone) allows flavin cofactors to sit at the crossroads of two-electron and one-electron transfer chains. That is, they can be reduced by organic substrates two electrons at a time and be reoxidized by either obligate one-electron acceptors such as cytochromes (e.g., yeast cytochrome b2 or cytochrome b5 reductase/cytochrome b5) and iron-sulfur cluster proteins (adrenodoxin reductase/adrenodoxin) or by facultative one-electron acceptors such as benzoquinones (coenzyme... 

Ferran, E. A. Ferrara, P. (1992). Clustering proteins into families using artificial neural networks. Comput Appl Biosci 8,39-44. 

Ferran, E. A. Pflugfelder, B. (1993). A hybrid method to cluster protein sequences based on statistics and artificial neural networks. ComputAppl Biosci 9,671-80. 

R. Debus, ed. The Catal)4ic Manganese Cluster-Protein Ligation, in Photosystem II The Water/Plastoquinone Oxido-ReductaseinPhotosynthesisfeds.T. Wydrzynski and K. Satoh, Springer, The Netherlands, 2005, Chap. 11. 

Similar to E. coli, yeast down-regulate the transcription of non-essential proteins that require iron for activity when the cells become depleted of iron. BI02 and GLTl encode iron-sulfur cluster proteins that are involved in the synthesis... 

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