Adrenodoxin reductase structure

The crystal structure of NADPH-cytochrome P450 reductase (CPR), the common electron-transfer protein of Class 11 eukaryotic P450 systems, was reported in 1997. This was followed by the structures of adrenodoxin reductase (AdR) and adrenodoxin (Adx), the two electron-transfer proteins of the Class 1 mitochondrial P450 system. The crystal structure of a cross-linked AdR-Adx complex has also been reported. " Putidaredoxin reductase (PdR) and putidaredoxin (Pd) of the P450cam system have also been structurally characterized. ... 

Figure 8 The structures of the FAD-containing adrenodoxin reductase (AdR) and the Fe2S2 ferredoxin adrenodoxin (Adx) cross-linked by the side chains of Lys27 of AdR and Asp39 of Adx. The distance of closest approach of the two redox centers is...

Muller, J.J., A. Lapko, G. Bourenkov, K. Ruckpaul, and U. Heinemann (2000). Adrenodoxin reductase-adrenodoxin complex structure suggests electron transfer path in steroid biosynthesis. J. Biol. Chem. 276, 2786-2789. 

Ziegler, G.A., C. Vonrhein, I. Hanukoglu, and G.E. Schulz (1999). The structure of adrenodoxin reductase of mitochondrial P450 systems Electron transfer for steroid biosynthesis. J. Mol. Biol. 289, 981-990. 

Figure 3.14. Structures of the adrenodoxin (Adx)-andrenodoxin reductase (Adr) complex, putidaredoxin (Pdx), and putidaredoxin reductase (Pdr). For comparisons, the structure of glutathione reductase also is shown.

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