Proteins with Dehydron Clusters

A curated PDB-derived database was constructed free of redundancy for singledomain proteins with contour length N 50. The database is comprised of 2,982 entries with 50% pairwise identity in aligned sequences. Proteins were grouped according to n, the size of the dehydron cluster in the structure. The groups intersect 

5 Under-Wrapped Proteins in the Order-Disorder Twilight 

6 Misfolding and Aggregation Consequences of a Massive Violation of Architectural Constraints 

As noted in Chap. 2, the worse wrapped proteins are potassium channel neurotoxins but their buttressing is actually adequate for an extracellular protein with such a level of structural deficiency. 

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In this chapter we identify functional indicators of PDB-reported soluble proteins with clusters of dehydrons. Such regions, rich in structural vulnerabilities, may be characterized as belonging to a twilight zone between order and native disorder [4], This characterization is already suggested by a strong correlation between wrapping of intramolecular hydrogen bonds (p) and propensity for structural disorder (/d), as shown in Fig. 5.1. The correlation reveals that the inability to exclude... 

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