Closed bottle test

Figure 9.6 Biodegradability of structurally related antineoplastics [113] (CBT— closed bottle test ZWT = Zahn-Wellens test).

Al-Ahmad, A., Ktimmerer, K. and Schon, G. (1997) Biodegradation and toxicity of the antineoplastics mitoxantron hydrochloride and treosulfane in the Closed Bottle Test (OECD 301 D). Bull. Environ. Contam. Toxicol., 58 (5), 704—711. 

Kiimmerer, K., Steger-Hartmann, T., Baranyai, A. and Burhaus, 1. (1996) Examination of the biodegradation of the antineoplastics cyclophosphamide and ifosfamide with the Closed Bottle Test (OECD 301 D). Zentratbl. Hyg. Umweltmed., 198 (3), 215-225. 

Roberts, D.J., Rabke, S. and Bernier, R. (2005) Evaluation of marine sediment qualities and their effect on the marine closed bottle test for testing biodegradability of synthetic drilling mud base fluids. SPE 94430 SPE/EPA//DOE Exploration and Production Environmental Conference 7-9 March 2005, Galveston, TX. Society of Petroleum Engineers, Richardson, TX, pp. 7. 

Biodegradation test methods By using the test method summaries of Table 7.1, explain the differences in concept of CEC and Close bottle test. Why the presence of additives (nitrogen and phosphorus excluded) in the lubricants is known to have a significant effect on the rate of biodegradation ... 

Ready Closed bottle test (67/S48/EEC) EC V.C.4-E ISO N. 160 OECD 301D 02 only 60% or greater... 

A9.4.3.5.6 Volatile substances should only be tested in closed systems as the Closed Bottle test (OECD Test Guideline 30ID), the MITI I test (OECD Test Guideline 301C) and the Manometric Respirometry test (OECD Test Guideline 30IF). Results from other tests should be evaluated carefully and only considered if it can be demonstrated, e.g. by mass balance estimates, that the removal of the test substance is not a result of volatilization. 

ISO 10707 (1994). Water quality - Evaluation in an aqueous medium of the ultimate biodegradability of organic compounds - Method by analysis of biochemical oxygen demand (closed bottle test)... 

D Closed Bottle Test E Modified OECD Screening Test... 

OECD 301D, 1993, Ready biodegradability Closed Bottle Test - 301 D. Guidelines for testing of chemicals. Organization for Economic Cooperation and Development (OECD), Paris, France. 

MOST, Modified OECD Screening Test CB, Closed Bottle Test Stunn-Test. Without sludge exchange. 

Thiram causes no BOD under the strict conditions of the closed bottle test. This result does not exclude the possibility that the product may be degraded in the environment. 

Theoretical oxygen demand (TOD) calculated for complete oxidation to carbon dioxide and water. Biochemical oxygen demand (BOD) expressed as a percentage of theoretical oxygen demand (closed bottle test). 

ISO 10708 1997 Water quality—evaluation in aqueous medium of ultimate aerobic biodegradability of oiganic compounds determination of biochemical oxygen demand in a two-phase closed-bottle test... 

Stepnowski et al. [46] used the closed bottle test to examine the biodegradability of 1-alkoxymethyl-3-hydroxyp5midinium cations combined with acesulfamate, saccharinate and chloride anions. A set of oxygenated and non-oxygenated imidazolium-based ionic liquids... 

Not readily biodegradable (closed bottle test). Inhibition of activated sludge organisms at a concentration of 96mg/kg sludge/120h (Sapromat test). 

Not readily biodegradable according to OECD/EC guidelines. Biodegradation reached in Closed Bottle Test after 20 days 38%. 

Ecotoxicity Degradability > 80% (closed bottle test). Activated sludge organisms are not inhibited by concentrations of 200mg/l. 

Teratogenicity study in rabbits, dermal application no teratogenic effects at 300mg/kg/day. Ecotoxicity Not easily biodegradable degree of elimination 14% (closed bottle test). 

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