Cloquintocet-mexyl

Cloquintocet-mexyl was developed under the code CGA 185072 by Ciba-Geigy (now Syngenta) and is used post-emergence in cereals. The basic patent (EP 94349) has a priority date of 7 May 1982. Various other country patents followed (e.g., US4902340 and US 5102445). It was first reported in 1989 [13] alongside the ACCase inhibitor clodinafop-propargyl, and till now the main use of 

Cloquintocet-mexyl has a favorable toxicological profile (Table 5.6). 

In the soil cloquintocet-mexyl degrades rapidly to the free acid (DT50 3 days) with further degradation and mineralization within weeks or a few months. The parent safener and major metabolites are reported to bind strongly to soil and hence have low leaching potential. 

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Figure 3. Dose-response curve highlighting safener efficacy and selectivity margin of the specific pinoxaden plus cloquintocet-mexyl combination (—) in contrast to treatments without safener ( -).

Pinoxaden, Axial , Adigor , Cloquintocet-mexyl, Discovery, Structure-Activity Relationship, Herbicide, Grass Weed Control, Graminicide, Postemergence, Cereals, Wheat, Barley... 

The effect of the safener cloquintocet-mexyl on the biokinetics and metabolism of pinoxaden in barley, winter and durum wheats, Avena fatua and Lolium rigidum was studied with the radiolabeled herbidde [89]. Safening is achieved by enhancing the metabolism of pinoxaden within the crop (Table 9.7). 

Table 9.7 Pinoxaden was applied at a rate equivalent to 90 g ha with the adjuvant A12127 used at 0.5%. Leaves treated with 20 x 0.2 mL droplets containing " C-labeled pinoxaden at 4000 dps. Treatments were made up with or without cloquintocet-mexyl (S) added at 25% the rate of the herbicide (H). Barley cv Manitou), Winter wheat (ci Soisson), Durum wheat cv Colossea).

NOTE The safeners cloquintocet-mexyl and fluxofenim are included for comparison purposes. 

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