Clofibrate

Fibric Acid Derivatives. Fibtic acid derivatives have been used since the 1960s for control of blood Upid levels. The four most well-known compounds in this class ate fenofibrate, gemfibrozil, clofibrate, and bezafibrate, shown in Table 5. Fenofibrate has been the most popular fibtic acid derivative in Europe, and has mote tecentiy been investigated extensively in clinical trials in the United States (153). Bezafibrate is stmcturaHy related to clofibrate, and has tecentiy been reviewed by Western European and AustraUan clinical trials (154). [Pg.131]

Clofibrate, shown to be an effective Upid lowering dmg in the eady 1960s, is the ethyl ester of/ -chlotophenoxy isobutyric acid. Gemfibrozil is a stmctural congener of clofibrate. [Pg.131]

Disubstituted aryloxyacetic acid derivatives related to clofibrate have been intensively studied in an attempt to get around the side effects of the latter drug. [Pg.44]

Ciprofibrate (48), a more potent lipid-lowering agent clofibrate, is prepared from Simmons-Smith product by Sandmeyer replacement of the amino group by a hydroxyl via the diazonium salt. Phenol undergoes the Reimer-Thiemann like process common to these agents upon alkaline treatment with acetone and chloroform to complete the synthesis of ci profib-rate (48). [Pg.44]

Bephenium hydroxy nephthoate a-(p-Chlorophenoxy)isobutyric acid Clofibrate... [Pg.1623]

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