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Probenecid Clofibrate

Interactions with the following drugs may increase the risk of hypoglycemia other hypoglycemics, sulfonamides, propranolol, salicylates, clofibrate, probenecid, pentamidine, valproic acid, dicumarol, cimetidine, MAO inhibitors, and alcohol. In addition, co-ingestion of alcohol may occasionally produce a disulfiram-like interaction (see p 186). [Pg.94]

Drugs that may be affected by probenecid include acyclovir allopurinol barbiturates benzodiazepines clofibrate dapsone dyphylline methotrexate NSAIDs pantothenic acid penicillamine rifampin sulfonamides sulfonylureas zidovudine salicylates. [Pg.948]

Probenecid Interference with renal excretion of drugs that undergo active tubular secretion, especially weak acids. Inhibition of glucuronide conjugation of other drugs. Clofibrate [P] Reduced glucuronide conjugation of clofibric acid. [Pg.1602]

Probenecid Clofibric acid -fr Nonrenal CL decreased by 72%, free clofibric acid C, increased 3.6-fold 113... [Pg.102]

Veenendaal JR, Brooks PM, Meffin PJ. Probenecid-clofibrate interaction. Clin Pharmacol Ther 1981 29(3) 351-358. [Pg.120]

Meffin PJ, Zilm DM, Veenendaal JR, et al. A renal mechanism for the clofibric acid-probenecid interaction. J Pharmacol Exp Ther 1983 227(3) 739-742. [Pg.121]

Benzodiazepines Clofibric acid Ethacrynic acid Fenoprofen Flufenamic acid Ibuprofen Naproxen Probenecid... [Pg.336]

Ceftriaxone (A) Clindamycin (A) Clofibrate (A) Dexamethasone (N) Diazepam (B) Diazoxide (A) Dicloxacillin (N) Digitoxin (N) Etoposide (N) Ibuprofen (A) Indomethacin (A) Nafcillin (A) Naproxen (A) Oxacillin (A) Phenylbutazone (A) Phenytoin (A) Probenecid (A) Salicylic acid (A) Sulfisoxazole (A) Teniposide (N) Thiopental (A) Tolbutamide (A) Valproic acid (A) Warfarin (A)... [Pg.3031]

Plasma clofibrate levels can be approximately doubled by probenecid, but the clinical significance of this is unclear. [Pg.1091]

A pharmacokinetic study in 4 healthy subjects taking clofibrate 500 mg every 12 hours found that probenecid 500 mg every 6 hours for 7 days almost doubled the steady-state clofibric acid levels, from 72 to 129 mg/L, and raised the free clofibric acid levels from 2.5 to 9.1 mg/L. The suggested reason is that the probenecid reduces the renal and metabolic clearance of the clofibrate by inhibiting its conjugation with glucuronic acid. The clinical importance of this interaction is uncertain. It appears not to have been assessed. [Pg.1091]

See other pages where Probenecid Clofibrate is mentioned: [Pg.1091]    [Pg.1091]    [Pg.690]    [Pg.12]    [Pg.94]    [Pg.125]    [Pg.179]    [Pg.179]    [Pg.306]    [Pg.10]    [Pg.94]    [Pg.125]    [Pg.179]    [Pg.306]    [Pg.96]    [Pg.106]    [Pg.107]    [Pg.498]    [Pg.10]    [Pg.94]    [Pg.125]    [Pg.179]    [Pg.471]   
See also in sourсe #XX -- [ Pg.1091 ]



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Clofibrate

Probenecid

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