Clofibric add

K. Veronich, G, White, and A. Kapoor, Effects of phenylbutazone, tolbutamide and clofibric add on binding of racemic warfarin and its enantiomers to human serum albumin, J. Pharm. Sci., 68 1515 (1979). 

Fig. 7.6 Chemical structures of fibric acid and its derivatives. Fenofibrate (a) clofibric add (b) rosigUtazone (c) fenofibric add (d) and clofibrate (e)...

Fibric adds Clofibrate Gemfibrozil Fenofibrate Increase VLtt-catabolism PPAR , agonist LDLi 5-20% HDL t 10%-20% TG i 20%-S0% Gl upset, dyspepsia, gallstones, T LFTs, myopathy Nonmetabolism Warfarin Cyclosporine Statins Liver or severe renal disease primary biliary cirrhosis preexisting gallbladder disease... 

Gottlicher, M., Widmark, E., li, Q., and Gustafsson, J. A. (1992). Fatty adds activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc Natl Acad Sci USA 89, 4653-4657. 

Fig. 2. Ketogenesis from palmitate (16 0) and different unsaturated fatty adds in isolated hepatocytes from rats fed low fat pellets open columns) and low fat pellets + 0.3% clofibrate hatched columns). The cells were incubated with the different fatty adds in a concentration of 2 mM...

Carlson, L.A., and Rosenhamer, G., 1988. Reduction of mortality in the Stockholm Ischaemic Fleart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic add. Acta Medica Scandinavica. 223 405 18. 

Bezafibrate, gemfibrozil, clofibrate, fenofibrate, dofibric add Metoprolol, propranolol, betaxolol, bisoprolol, terbutalin, salbutamol, atenolol, sotalol, fenoterol, nadolo, timolol Tamoxifen, Ifosfamide, cydophosphamide, carbamazepine, diazepam,... 

Muerhoff, A.S., Griffin, K.J. Johnson, E.F. (1992) J. Biol. Chem. 267, 19051-19053, The peroxisome prohferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty add omega-hydroxylase, by clofibric acid. 

Investigation of the 3-hydroxyacyl-CoA dehydrogenase activities in purified rat liver peroxisomes, using the 3-hydroxyacyl-CoAs of straight chain fatty adds, of 2-methyl-branched chain fatty adds and of trihydroxycoprostanic add as substrates, revealed initially 5 different enzymes (named I to V). Enzyme IV was a monomeric 78 kD protein, possessed crotonase activity, was induced by clofibrate, and was identified as the indudble multifunctional protein. Interestingly, enzyme III, a monomeric 80 kD protein, also hydrated crotonyl-CoA. In contrast to enzyme IV, enzyme HI was not induced by clofibrate. This was the first indication, published in IW, that peroxisomes contained a second multifunctional protein. It was named multifunctional protein 2 (MFP-2) (the inducible, firstly isolated protein is referred to as MFP-1). Based on its substrate spectrum, the newly identified multifunctional protein was postulated to be involved in bile acid formation. ... 

MizugaM, M., Nishimaki, T., Yamamoto, H., Sagi, M. Yamanaka, H. (1982) J. Biochem., 92. 2051-2054, Studies on the metabolism of unsaturated fatty adds. XI. Alterations in the activities of enoyl-CoA hydratase, 3-hydroxyacyl-CoA epimerase and 2,4-dienoyl-CoA reductase in rat hver mitochondria and peroxisomes by clofibrate. 

Mannaerts, G.P., Debeer, L.J., Thomas, J. DeShepper, P.J. 1979. J. Biol. Chem., 254, 4585-4595. Mitochondrial and peroxisomal fatty add oxidation in Ever homogenates and isolated hepatocytes from control and clofibrate treated rats. 

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