Danazol Cyclosporine

Passfall J, Keller F. Pharmacokinetics of danazol-cyclosporin interaction. NephrolDial Transplant ( 994) 9,1055. 

Cyclosporine alone fewer remissions than combination with ATG Androgens (such as Danazol—see dosing in ITP section)—can take 3 or more months to show effect... 

Drugs that maybe affected by danazol are carbamazepine, cyclosporine, and warfarin. 

Drugs that may affect tacrolimus include nephrotoxic agents (aminoglycosides, amphotericin B, cisplatin, cyclosporine), antifungals, bromocriptine, calcium channel blockers, cimetidine, clarithromycin, danazol, diltiazem, erythromycin, methylprednisolone, metoclopramide, carbamazepine, phenobarbital, phenytoin, rifamycins, cisapride, chloramphenicol, metronidazole, nefazodone, omeprazole, protease inhibitors, macrolide antibiotics, fosphenytoin, and St. John s wort. 

Drugs that may increase sirolimus blood concentrations include the following Nicardipine, verapamil, clotrimazole, fluconazole, itraconazole, clarithromycin, erythromycin, troleandomycin, cisapride, metoclopramide, bromocriptine, cimetidine, danazol, HIV-protease inhibitors, cyclosporine, diltiazem, azole antifungals. 

Drugs that may affect cyclosporine include allopurinol, amiodarone, androgens (eg, danazol, methyltestosterone), anticonvulsants (eg, carbamazepine, phenobarbital, phenytoin), azole antifungals (eg, fluconazole, ketoconazole), beta-blockers, bosentan, bromocriptine, calcium channel blockers, colchicine, oral contraceptives, corticosteroids, fluoroquinolones (eg, ciprofloxacin), foscarnet, HMG-CoA reductase inhibitors, imipenem-cilastatin, macrolide antibiotics, methotrexate, metoclopramide, nafcillin, nefazodone, orlistat, potassium-sparing diuretics, probucol, rifamycins (rifampin, rifabutin), serotonin reuptake inhibitors (SSRIs eg, fluoxetine, sertraline),... 

Ezetimibe/Simvastatin (Vytorin) [Antilipemic/HMG CoA Reductose Inhibitor] Uses H rp cholest olemia Action X Absorption of cholesterol phytost ol w/ HMG-CoA reductase inhibitor Dose 10/10-10/80 mg/d PO w/ cyclosporine or danazol 10/10 mg/d max w/ amio-darone or verapamil 10/20 mg/d max -1- w/ sev e renal insuff Caution [X, -] w/ CYP3A4 inhibitors (Table VI-8), gemfibrozil, niacin >lg/d, danazol, amiodarone, verapamil Contra PRG/lactation livCT Dz, t LFTs Disp Tabs SE HA, GI upset, myalgia, myopathy (muscle pain, weakness, or tendOTiess w/ CK 10 x ULN, rhab-domyolysis), Hep, Infxn Interactions t Risk of myopathy W7 clarithromycin, erythromycin, itraconazole, ketoconazole EMS None OD Sxs unknown symptomatic and supportive... 

Clarithromycin Cimetidine Danazol Bromocriptine Methylprednisolone Metoclopramide Cyclosporine... 

Abacavir Adinazolam 5-Aminosalicylic acid Atorvastatin Avitriptan Bromazepam Bumetanide Celecoxib CGP 43371 Clodronate Cyclosporin Danazol Didanosine Erythromycin Fexofenadine Furosemide Ganciclovir Halofantrine Inidnavir Itraconazole Levofloxacin Methotrexate Nifedipine Pravastatin Rifabutin Stavudine Tacrine... 

Clinically important, potentially hazardous interactions with amiodarone, beta-blockers, caspofungin, cyclosporine, dairy products, danazol, erythromycin, etoricoxib, grapefruit juice, hemophilus B vaccine, HMG-CoA reductase inhibitors, ibuprofen, immunosuppressants, ketoconazole, lopinavir, lovastatin, mycophenolate, peanuts, potassium, potassium-sparing diuretics, rifabutin, rifampin, rifapentine, simvastatin, St John s wort, telithromycin, vaccines... 

Urokinase, danazol, dapsone, sodium cromoglycate, and plasma exchange have also been evaluated, but none is consistently effective nor shown to affect renal function. Cyclosporine treatment for 12 weeks was evaluated in nine patients. FToteinuria was reduced and plasma albumin concentrations increased. However, the creatinine clearance decreased during treatment and did not return to baseline after termination of cyclosporine therapy. Cyclosporine is not, therefore, indicated for patients with IgA nephropathy. 

Ross WB, Roberts D, Griffin PJA and Salaman JR Cyclosporin interaction with danazol and norethisterone.Lawce (1986) i, 330. 

Blatt J, Howrie D, Orlando S. Burckart G. Interaction between cyclosporine and danazol in a pediatric paXxtnl JPediatrHematol Oncol 996) 18, 95. 

Borras-Blasco J, Rosique-Robles JD, Peris-Marti J, Navarro-Ruiz J, Gonzalez-Delgado Conesa-Garcia V. Possible cyclosporin-danazol interaction in a patient with aplastic anaemia. AmJHematol( 999) 62, 63-4. 

Koneru B, Hartner C, I watsuki S, Starzl TE. Effect of danazol on cyclosporine pharmacokinetics. Transplantation (1988) 45,1001. 

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