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Clodronate

Bone Metabolism. Figure 3 Chemical structure of pyrophosphate (a) and the bisphosphonates etidronate (b), clodronate (c), pamidronate (d), ibandronate (e). alendronate (f), risedronate (g), zoledronate (h). [Pg.281]

C, H2 Cl206P2 10596-22-2) see Clodronate disodium dichloromethyl methyl ether (C2H4CI2O 4885-02-3) see Clidanac... [Pg.2347]

GjHjiOjP 116-17-6) see Clodronate disodium (3/t,45)-3-(triisopropylsilyloxy)-4-phenyl-2-azetidinone (C nH2()N02Si 132127-31-2) see Docetaxel triisopropylsilyl trifluoromethanesulfonate (C ()H2 F303SSi 80522-42-5) see Tacrolimus... [Pg.2451]

Virtanen, V. and Lajunen, L. H. J., High-performance liquid chromatographic method for simultaneous determination of clodronate and some clodronate esters, /. Chromatogr., 617, 291, 1993. [Pg.284]

Raiman J, Tormalehto S, Yritys K, Junginger HE, Monkkonen J (2003) Effects of various absorption enhancers on transport of clodronate through Caco-2 cells. Int J Pharm 261 129-136. [Pg.211]

The highly polar clodronic acid (9.53, R, R = Cl), etidronic acid (9.53, R = Me, R = OH), and a number of analogues have demonstrated their clinical value in the treatment of osteoporosis, but they must often be administered by slow intravenous infusion due to their poor oral bioavailability. Esterification to orally available prodrugs is, thus, an actively investigated strategy. Promising results have, for example, been obtained with (pivaloyl-oxy)methyl esters of clodronic acid [120]. [Pg.581]

R. Niemi, J. Vepsalainen, H. Taipale, T. Jarvinen, Bisphosphonate Prodrugs Synthesis and in vitro Evaluation of Novel Acyloxyalkyl Esters of Clodronic Acid , J. Med. Chem. 1999,42, 5053-5058. [Pg.603]

Figure 2 Effect of liposomal formulations BPs (alendronate and clodronate), empty and free drugs on RAW 264 cell survival. Curves represent percentage of cell inhibition with different BP concentrations. Cell count in buffer only was determined to be 100% (n = 3). Abbreviation BPs, bisphosphonates. Source From Ref 69. Figure 2 Effect of liposomal formulations BPs (alendronate and clodronate), empty and free drugs on RAW 264 cell survival. Curves represent percentage of cell inhibition with different BP concentrations. Cell count in buffer only was determined to be 100% (n = 3). Abbreviation BPs, bisphosphonates. Source From Ref 69.
Figure 3 Time response of CD14+ monocytes, expressed as percentage of total blood leukocytes, in LC-treated and control balloon-injured rabbits and control. Abbreviations. WBC, white blood cells LC, liposomal clodronate. Source From Ref. 52. Figure 3 Time response of CD14+ monocytes, expressed as percentage of total blood leukocytes, in LC-treated and control balloon-injured rabbits and control. Abbreviations. WBC, white blood cells LC, liposomal clodronate. Source From Ref. 52.
The rat carotid artery injured by a balloon catheter has been widely used as a model of angioplasty. The rat model is a proliferation model without foam cells (93). This form of injury causes immediate coagulation and thrombosis cascade in which platelets adhere, spread, and degranulate on the denuded surface of the artery, and approximately 24 hours later SMC begin to proliferate. Liposomal BPs, clodronate, and alendronate were injected to male sabra rats, 15 and 3mg/kg, respectively (52,69,76). Marked neointimal formation and decreased luminal area were observed in control animals. Neointima/media (N/M) ratio was 1.3 0.2, and luminal stenosis was 44 3%. LC and LA suppressed intimal growth when administered intravenously on day -1 and day 6. N/M ratios were reduced by 60% and 69% for LC and LA, respectively. [Pg.197]

Danenberg HD, Fishbein 1, Gao J, et al. Macrophage depletion by clodronate-containing liposomes reduces neointimal formation after balloon injury in rats and rabbits. Circulation 2002 106 599-605. [Pg.203]

Selander KS, Monkkonen J, Karhukorpi EK, Harkonen P, Hannuniemi R, Vaananen HK. Characteristics of clodronate-induced apoptosis in osteoclasts and macrophages. Mol Pharmacol 1996 50 1127-1138. [Pg.204]

Monkkonen J, Pennanen N, Lapinjoki S, Urtti A. Clodronate (dichloromethy-lene bisphosphonate) inhibits LPS-stimulated IL-6 and TNF production by Raw-264 cells. Life Sci 1994 54 P1229-P1234. [Pg.204]

Monkkonen J, Liukkonen J, Taskinen M, Heath TD, Urtti A. Studies on liposome formulations for intraarticular delivery of clodronate. J Control Release 1995 35 145-154. [Pg.204]

Makkonen N, Salminen A, Rogers MJ, et al. Contrasting effects of alendronate and clodronate on RAW 264 macrophages the role of a bisphosphonate metabolite. Eur J Pharm Sci 1999 8 109-118. [Pg.205]

Monkkonen J, Valjakka R, Hakasalo M, Urtti A. The effects of liposome surface-charge and size on the intracellular delivery of clodronate and gallium in-vitro. Int J Pharm 1994 107 189-197. [Pg.205]

Huikko, K., and Kostiainen, R. (2000). Development and validation of a capillary zone electrophoretic method for the determination of bisphosphonate and phosphonate impurities in clodronate./. Chromatogr. A 893(2), 411-420. [Pg.167]

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Bisphosphonate drug clodronate

Clodronate disodium

Clodronate hypercalcaemia

Clodronic acid

Liposomal clodronate

Sodium clodronate

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