Clinical pharmacology overview

Product Development Rationale Overview of Biopharmaceutics Overview of Clinical Pharmacology Overview of Efficacy Overview of Safety Benefits and Risks Conclusions Literature References... 

Joshi, A., Bauer, R., Kuebler, P, White, M., Leddy, C., Compton, P., Garovoy, M., Kwon, P., Walicke, P., and Dedrick, R. 2006. An overview of the pharmacokinetics and pharmacodynamics of efalizumab a monoclonal antibody approved for use in psoriasis. Journal of Clinical Pharmacology 46(1), 10-20. 

The present short overview of medicines regulation is clearly not comprehensive but rather an attempt to give idea about the complexities of this important area of work that has many direct links with clinical pharmacology. Clinical pharmacologists as medical specialists equipped with unique knowledge about medicines have a role and responsibility to develop and contribute to medicines regulation. 

Mirakhur RK. Newer neuromuscular blocking drugs An overview of their clinical pharmacology and therapeutic use. Drugs 1992 44 182-99. 

Tan, A.C., F.G. Russel, T. Thien, and T.J. Benraad. 1993. Atrial natriuretic peptide. An overview of clinical pharmacology and pharmacokinetics. Clin. Pharmacokinet. 24 28-45. 

Britt GC, McCance-Katz EF. A brief overview of the clinical pharmacology of club drugs . Subst Use Misuse 2005 40 1189-201. 

Dennis MJ, Beijnen JH, Grochow LB, van Warmerdam LJ. An overview of the clinical pharmacology of topotecan. Semin Oncol 1997 24(1 Suppl 5) S5-12-5-18. 

Small, RC. and Foster, RW. (1986). Airway smooth muscle An overview of morphology and aspects of pharmacology In Asthma Clinical Pharmacology and Therapeutic Progress (ed A.B. Kay) pp. 101-113, Blackwell, Oxford. 

Drayer, D.E. (1986) Pharmacodynamic and pharmacokinetic differences between drug enantiomers in humans an overview. Clinical Pharmacology and Therapeutics, 40, 125-133. 

Table 3.4 An Overview of the Clinically Marketed Hg-R Antagonists Affinity, Clinical Pharmacology, and Pharmacokinetic Profile "... 

Merck Manual of Diagnosis and Therapy. Sec. 22 Clinical Pharmacology. URL http //www.merck.com/mrkshared/ mmanual/section22/sec22.jsp. [25 October 2005]. Free Web version of the Merck Manual. Clinical Pharmacology section provides an overview of the basic concepts of pharmacokinetics, pharmacodynamics, and toxicity. 

An Overview of Clinical Pharmacology subsection is to present an analysis of PK, pharmacodynamic (PD), and related in vitro data. This analysis is to consider all relevant data, discuss how and why the data support the conclusions drawn, and emphasize unusual results and known or potential problems. Items to be addressed in this subsection include... 

Perri, D., Ito, S., Rowsell, V., Shear, N. H. (2003). The kidney The body s playground for drr s An overview of renal drug handling with selected clinical correlates. The Canadian Journal of Clinical Pharmacology = Journal Canadien de Pharmacologic Clinique, 10, 17—23. 

Mullangi, R., and Srinivas, N.R., 2011. Niacin and its metabolites role of LC-MS/MS bioanalytical methods and update on clinical pharmacology. An overview. Biomedical Chromatography. 25 218-237. 

This module should be prefaced by a brief introduction outlining the pharmacological class, mode of action and proposed clinical use of the dmg. The overview reports form the most important part of this module as they introduce the reviewer to the case that the applicant wishes to put forward in favour of authorisation of the drug for the... 

Overview of the non-clinical testing strategy Pharmacology Pharmacokinetics Toxicology... 

Pertwee RG (1995). Pharmacological, physiological and clinical implications of the discovery of cannabinoid receptors An overview. In R Pertwee (ed.), Cannabinoid Receptors (pp. 829-832). Raven Press, New York. 

In this article, we have presented an overview of the development and pharmacology of the different classes of PAF antagonists. These compounds counteract diverse pathologies in various animal models and are now undergoing clinical investigation in human disease, where the initial results seem en-... 

Mystakidou K, Katsouda E, Parpa E, Vlahos L, and Tsitas ML (2006) Oral trans-mucosal fentanyl citrate Overview of pharmacological and clinical characteristics. Drug Deliv. 13 269-276. 

Module 2 Common technical document summaries Overall common technical document table of contents Introduction Quahty overall summary Non-chnical overview Clinical overview Non-chnical summary Pharmacology Written summary Tabulated summary Pharmacokinetics Written summary Tabulated summary Toxicology... 

Handbook of Experimental Pharmacology, we are happy to present an overview on the current state of basic and clinical research on Anxiety and Anxiolytic Drugs . 

Preskorn, S.H. (1997) Clinically relevant pharmacology of selective serotonin reuptake inhibitors. An overview with emphasis on pharmacokinetics and effects on oxidative drug metabolism. Clin Pharmacokinet 32 1-21. 

Wiederhold NP, Lewis RE The echinocandin antifungals An overview of the pharmacology, spectrum and clinical efficacy. Expert Opin Investig Drugs 2003 12 1313. [PMID 12882619]... 

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