Pharmacology overview

Product Development Rationale Overview of Biopharmaceutics Overview of Clinical Pharmacology Overview of Efficacy Overview of Safety Benefits and Risks Conclusions Literature References... 

Nutescu EA, Shapiro NL, Chevalier A, et al. A pharmacologic overview of current and emerging anticoagulants. Cleve Clin J Med 2005 72(suppl l) S2-S6. 

Zuardi AW, Guimaraes FS (1997) Cannabidiol as an anxiolytic and antipsychotic. In Mathre ML (ed) Cannabis in medical practice a legal, historical and pharmacological overview of the therapeutic use of marijuana. McFarland, Jefferson, pp 133-141... 

Zuardi, A.W. and Guimaraes, F.S. (1997) Cannabidiol as an anxiolytic and antipsychotic, in Cannabis in Medical Practice A Legal, Historical and Pharmacological Overview of the Therapeutic Use of Marijuana. M.L. Mathre, Ed. pp. 133-141, McFarland, Jefferson, NC. 

Zanger UM, Eichelbaum M (2004) Cytochrome P450 2D6 overview and update on pharmacology, genetics, biochemistry. Naunyn Schmiedebergs Arch Pharmacol 369 23-37... 

This module should be prefaced by a brief introduction outlining the pharmacological class, mode of action and proposed clinical use of the dmg. The overview reports form the most important part of this module as they introduce the reviewer to the case that the applicant wishes to put forward in favour of authorisation of the drug for the... 

Overview of the non-clinical testing strategy Pharmacology Pharmacokinetics Toxicology... 

After an overview of neurotransmitter systems and function and a consideration of which substances can be classified as neurotransmitters, section A deals with their release, effects on neuronal excitability and receptor interaction. The synaptic physiology and pharmacology and possible brain function of each neurotransmitter is then covered in some detail (section B). Special attention is given to acetylcholine, glutamate, GABA, noradrenaline, dopamine, 5-hydroxytryptamine and the peptides but the purines, histamine, steroids and nitric oxide are not forgotten and there is a brief overview of appropriate basic pharmacology. 

Figure 21.4 An overview of the pharmacological systems involved in the transmission and modulation of pain together with some drugs that act on these systems...

The present chapter will address the following issues (1) a very brief overview on the properties of the different types of Cl -channels in the various mammalian cells (2) a short summary on what is known of Cl channels on a molecular basis (3) a discussion of pharmacological agents blocking the various Cl -channels and (4) a specific section dealing with the regulation of epithelial and maybe other Cl -channels. This entire area has been reviewed rather extensively in the recent past. A large number of references will be provided in order to keep this text concise. The entire field of Cl -channels in the central nervous system will only be touched upon to compare these channels to the Cl -channels in apolar cells and epithelia. 

Chappie CR. Pharmacological therapy of benign prostatic hyperplasia/ lower urinary tract symptoms an overview for the practicing clinician. BJU Int 2004 94 738-744. 

Pertwee RG (1995). Pharmacological, physiological and clinical implications of the discovery of cannabinoid receptors An overview. In R Pertwee (ed.), Cannabinoid Receptors (pp. 829-832). Raven Press, New York. 

Joshi, A., Bauer, R., Kuebler, P, White, M., Leddy, C., Compton, P., Garovoy, M., Kwon, P., Walicke, P., and Dedrick, R. 2006. An overview of the pharmacokinetics and pharmacodynamics of efalizumab a monoclonal antibody approved for use in psoriasis. Journal of Clinical Pharmacology 46(1), 10-20. 

Cirelli, D.P. 1978. Patterns of pentachlorophenol usage in the United States of America — an overview. Pages 13-18 in K.R. Rao (ed.). Pentachlorophenol Chemistry, Pharmacology, and Environmental Toxicology. Plenum Press, New York. 

Buelke-Sam J, Bryant HU, Francis PC (1998) The selective estrogen receptor modulator, raloxifene an overview of nonclinical pharmacology and reproductive and developmental testing. Reprod Toxicol 12 217-221... 

In this article, we have presented an overview of the development and pharmacology of the different classes of PAF antagonists. These compounds counteract diverse pathologies in various animal models and are now undergoing clinical investigation in human disease, where the initial results seem en-... 

Mangan FR, Flack JD, Jackson D. Preclinical overview of nabumetone. Pharmacology, bioavailability, metabolism, and toxicology. Am J Med 1987 83(4B) 6-10. 

Mystakidou K, Katsouda E, Parpa E, Vlahos L, and Tsitas ML (2006) Oral trans-mucosal fentanyl citrate Overview of pharmacological and clinical characteristics. Drug Deliv. 13 269-276. 

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