Asthma clinical

Simons FE Is antihistamine (Hj-recep-tor antagonist) therapy useful in clinical asthma Clin Exp Allergy 1999 29 (suppl3) 98-104. 

Ramsey, L.A. University of Mississippi Pharmaceutical Care Clinics Asthma Outcomes, Private communication. 

The Late Asthmatic Response as a Model for Clinical Asthma... 

KUITERT, L.M., ANGUS, R.M., BARNES, N.C., BARNES, P.J., BONE, M.F., CHUNG, K.F., FAIRFAX, A.J., HIGENBOTHAM, T.W., O CONNOR, B J. PIOTROWSKA, B. (1995) Effect of a novel potent platelet-activating factor antagonist, modipafant, in clinical asthma. American Journal of Respiratory and Critical Care Medicine, 151, 1331-1335. 

Theophylline s predominant mode of action appears to be bronchocHlation. However, it has also been shown that prophylactic acHriinistration of theophylline provides some protection from asthma attacks and suppresses the late-phase response (67,68). Some researchers beHeve that at therapeutic semm concentrations theophylline may inhibit the development of airway inflammation (69). There are conflicting reports on the effect of theophylline on allergen-induced bronchial hyperresponsiveness some clinical stucHes report a reduction in hyper-responsiveness, others do not (69,70). Theophylline clearly does not reverse the general bronchial hyperresponsiveness over the course of long-term therapy (71). Because of the relationship between... 

Acetyl-P-methylcholine chloride [62-51-1/, commonly called methacholine chloride, is a parasympathornimetic bronchoconstrictor with clinical efficacy in bronchial asthma (45,46). 

The crude drug, Adhatoda vasica, is used in India as a remedy for asthma. According to Chopra, vasicine produces broncho-dilation and might be used clinically as an expectorant. A detailed pharmacological examination of peganine in comparison with harmine has been made by Tutaev and Makarova. ... 

Epinephrine itself does find some use in clinical medicine. The drug is used in order to increase blood pressure in cases of circulatory collapse, and to relax the bronchial muscle in acute asthma and in anaphylactic reactions. These activities follow directly from the agent s physiologic role. The biogenetic precursor of epinephrine, norepinephrine, has activity in its own right as a mediator of sympathetic nerve action. (An apocryphal story has it that the term nor is derived from a label seen on a bottle of a key primary amine in a laboratory in Germany N ohne... 

Selective AR agonists are undergoing clinical trials for cardiac arrhythmias and pain (Ai) cardiac imaging and inflammation (A2a) colon cancer, rheumatoid arthritis, psoriasis, and dry eye (A3). Selective AR antagonists are either in or advancing toward clinical trials for kidney disorders (Ax) Parkinson s disease (A2a) diabetes and asthma (A2B) cancer and glaucoma (A3). 

Given the routine use of mast cell stabilizers in the clinic, for example in the setting of asthma treatment, these preclinical results may stimulate clinical evaluation in humans. 

Airway inflammation is a characteristic clinical feature of asthma. The distinction between the LAR and chronic inflammation becomes more difficult as the disease progresses. Infiltrated leukocytes release ototoxic mediators such as reactive oxygen species (ROS) and cationic (basic) proteins causing epithelial damage and cyfo/cmas that perpetuate the inflammation. Sustained inflammation leads to airway hyperrespon-siveness and airway remodeling. 

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