Target Classes

Protein Kinase Class Target Sequence Activators... 

Herbicide class Target site Number of confirmed resistant biotypes... 

Target class Target subclass Target example Drug substance example (activity)... 

Bobeldijk, I. et al., Quantitative profiling of bile acids in biofluids and tissues based on accurate mass high resolution LC-FT-MS Compound class targeting in a metabo-lomics workflow, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 871(2), 306, 2008. 

Nyce J (2002). Respirable antisense oligonucleotides a new, third drug class targeting respiratory disease. Curr. Opin. Allergy Clin. Immunol. 2 533-536. 

Class Target Material Heavy Metals Pollution Notes Reference... 

While the previously mentioned attack class targets the P2P routing mechanism, other attacks against structured P2P networks exist [28,8], although they also require malicious peers colluding on behalf of an adversary. It is part of the future work to address these attacks in detail. Due to the natural physical distribution, it is unlikely that an attacker is able to hijack all peers that hold replicas of a specific datum at the same time this property of P2P networks provides protocol inherent resilience. 

Relative sensitivity class Target SO2 concentration (pg m - annual average)... 

Substructure searches provide another method of searching for available starting materials. They arc used primarily for planning the synthesis of combinatorial libraries. After the target compound has been dissected into a set of suitable precursors, substructure searches can provide for each of them a series of representatives of a certain class of compounds, Siibsti ucturc searches enable the user to specify attributes such as open sites or atom lists at certain positions of the structure. Figure 10.3-38 shows the possible specification elements for the query in a substructure search. 

Figure 10.4-1. Biochemical classes of the drug targets in current therapies.

In the last fifteen years macrolides have been the major target molecules for complex stereoselective total syntheses. This choice has been made independently by R.B. Woodward and E.J. Corey in Harvard, and has been followed by many famous fellow Americans, e.g., G. Stork, K.C. Nicolaou, S. Masamune, C.H. Heathcock, and S.L. Schreiber, to name only a few. There is also no other class of compounds which is so suitable for retrosynthetic analysis and for the application of modem synthetic reactions, such as Sharpless epoxidation, Noyori hydrogenation, and stereoselective alkylation and aldol reactions. We have chosen a classical synthesis by E.J. Corey and two recent syntheses by A.R. Chamberlin and S.L. Schreiber as examples. 

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