Target, targets classes

Niuiibcrs refer to the target level classes presented in Fig, 6.10. 

Fig. 1 Antiviral genes inhibit virus replication at different stages of the viral life cycle. Early inhibitors prevent the establishment of the viral genome in the target cell (class I, e.g., entry inhibitors, RT inhibitors for HIV). Intermediate inhibitors prevent viral gene expression or amplification of the viral genome (class II, e.g., siRNAs, antisense RNAs). Late inhibitors prevent virion assembly or release, or inactivate the mature virions (class III, e.g., transdominant core proteins, capsid-targeted virion inactivation, CTVI). A list of antiviral genes in each class is found in Table 1...

Kogej, T., Engkvist, O., Blomberg, N., Muresan, S. Multifingerprint based similarity searches for targeted class compound selection. J. Chem. Inf. Model. 2006, 46,1201-1213. 

The first step in the process involves the development of a suitable HTS assay format. A more detailed discussion of the formats available for HTS by target class are outlined later in this chapter. This section will focus on some of the practical considerations to determine the proper assay technology for an HTS campaign. 

Fig. 1 The distribution of current drugs by target class. Included in the figure is the current percent of market share...

Library designed, on the basis of preexisting information, to generate enhanced activity or hit rate against a particular biological target or target class. 

Figure 1.1 Distribution of marketed drugs by biochemical target class. GPCRs = G-Protein coupled receptors.

Figure 2.11 Plot of compounds developed for different target classes based on a principal components analysis (PCA) of 2D structure-based property fingerprints. Compounds are coded according to their target class (triangle, PDE square, 5HT receptor diamond, statin circle, F-quinoline antibiotics) and clinical status at the time (gray, ok yellow, clearance issue red,...

Target class Type af inhibitor Recognition element Reference... 

Medium-sized/Target-class Libraries and Collections 181... 

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