Target class approach

Approaches to Target Class Combinatorial Library Design... 

Other approaches that could be extended to target class library design include work by McGregor and Muskal (13,19). These utilized PharmPrint 3D pharmacophore descriptors (three-point pharmacophores) and partial least... 

Schnur, D. M. and Hermsmeier, M., Recent approaches to target class design, 36th MARM of the ACS, 2003. 

Schnur, D. M. (2001) Approaches to target class library design, CHI Conference on Molecular Diversity, San Diego, CA. 

Zheng, W. and Lampe, J. (2002) Combinatorial optimization approaches to the design of focused, diverse, and target class oriented libraries. Cambridge Healthtech Institute s Sixth Annual Cheminformatics, Philadelphia, PA. 

The biological activity displayed by the perhydroazulenes, ranging from diuretic and anti-inflammatory to antitumor, combined with the unique bicyclo [6-3-0] system make them very attractive synthetic targets. The approach of Trost and Higushi to this class of compounds, exemplified by the total synthesis of isoclavu-kerin 65 (Scheme 12.12) [34], has the distinctive feature that it allows the simultaneous formation of both the five- and seven-membered rings through a palladium-catalyzed formal [3+2] cyclization as its key step [35]. 

Methods and approaches that can simultaneously determine mixtures of drug candidates provide a powerful way to select an optimal drug candidate within a specific therapeutic area or a targeted class of compounds. Using relatively simple isolation and chromatography conditions, LC/MS/MS approaches are an effective way to evaluate new lead compounds for subsequent development. Consequently,... 

Schnur D, Beno BR, Good A, Tebben A (2004) Approaches to target class combinatorial library design. 

Summary of Published Approaches to One-Pot Syntheses Showing the Target Classes of Compounds and the Rationale for Process Integration... 

A very first proof that chemogenomic approaches might significantly increase the chances of success came from the target class of aspartyl proteases. During the 1980s, hundreds of man-years were spent in the search for orally available renin inhibitors, without much success. When HIV protease was recognized to be also... 

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