Ciprofloxacin dosing

Refer to source for details. In children, ciprofloxacin dose should not exceed Ig d , chloramphenicol should not exceed 4g d . Children younger than 2 years should not receive chloramphenicol... 

Transient bone marrow suppression occurred in a 50-year-old woman after 4 days therapy with ciprofloxacin (dose not specifled) for cystitis [26 ]. White blood cell and platelet counts fell to 1.5 x 10 /1 and 80 x 10 /1 respectively and normalized 3 days after ciprofloxacin withdrawal. 

Clinicians should be aware that dosage regimens with the same drug maybe different depending on the infectious process. For example, ciprofloxacin, a fluoroquinolone, has various dosage regimens based on site of infection. The dosing for uncomplicated UTIs is 250 mg twice daily for 3 days. For complicated UTIs, the dose is 500 mg twice daily for 7 to... 

Other FDA-approved antibiotics for ABRS not included in the Sinus and Allergy Health Partnership or AAP guidelines cefaclor, cefprozil, cefixime, ciprofloxacin, erythromycin, loracarbef. cMaximum dose not to exceed adult dose. 

The current drug of choice for typhoid fever is a fluoroquinolone, such as ciprofloxacin. The recommended dose of ciprofloxacin for uncomplicated typhoid is 500 mg orally twice daily for 5 to 7 days. Drug resistance is a recognized... 

The WHO and CDC recommended treatment regimens are shown in Table 77-5.37 There has been some debate about a suitable dosage of ciprofloxacin in the treatment of chancroid. Though the CDC recommends 500 mg orally three times daily, the WHO supports a single 500-mg oral dose. Ciprofloxacin has demonstrated an acceptable cure rate for a single dose (92%) when compared to erythromycin (91%). 

For penicillin-allergic adults, use a fluoroquinolone (ciprofloxacin 0.5-0.75 g orally every 12 hours or 0.4 g IV every 12 hours levofloxacin 0.5-0.75 g orally or IV every 24 hours or moxifloxacin 0.4 g orally or IV every 24 hours). eGentamicin or tobramycin, 2 mg/kg loading dose, then maintenance dose as determined by serum concentrations, fluoroquinolone or aztreonam 1 g IV every 6 hours may be used in place of the aminoglycoside in patients with severe renal dysfunction or other relative contraindications to aminoglycoside use. 

A single dose of IV cefazolin will provide adequate prophylaxis for most cases. Oral ciprofloxacin may be used for patients with /Tlactam hypersensitivity. 

Most frequently encountered organisms include E. colt, Klebsiella, and Enterococci. Single-dose prophylaxis with cefazolin is currently recommended. Ciprofloxacin and levofloxacin are alternatives for patients with /1-lactam hypersensitivity. 

Short-course therapy (3-day therapy) with trimethoprim-sulfamethoxazole or a fluoroquinolone (e.g., ciprofloxacin, levofloxacin, or norfloxacin) is superior to single-dose therapy for uncomplicated infection and... 

Avoid jejunal administration of ciprofloxacin Monitor clinical response Adjust warfarin dose based on international normalized ratio... 

Antibiotics Ciprofloxacin at 500 milligrams orally by mouth twice a day or doxycycline at 100 milligrams orally by mouth twice a day is the recommended drug and dose when... 

Drugs Use streptomycin at 15 mg/kg lean body mass intra-muscular every twenty-four hours for ten to fourteen days or use gentamicin at 5 mg/kg lean body mass intra-venous every twenty-four hours for ten to fourteen days or use gentamicin at 1.75 mg/kg lean body mass intra-venous every eight hours for ten to fourteen days or use ciprofloxacin at 400 mg intra-venous every twelve hours (oral therapy may be given at 750 mg orally every twelve hours after the patient is clinically improved, for completion of a ten to fourteen-day course of therapy) or use doxycycline at 200 mg intra-venous loading dose followed by 100 mg intra-venous every twelve hours (oral therapy may be given at 100 mg orally every twelve hours after the patient is clinically improved, for completion of a ten to fourteen-day course of therapy. 

In January 2001, at least 25 similar threats were received across Canada and the U.S. A typical case occurred at a Wal-Mart in Victoria, British Columbia, when a letter claiming to contain anthrax was received. Fortunately the letter did not contain anthrax, but before that could be conclusively established, the clerk who opened the letter received a precautionary dose of ciprofloxacin. 

Quinolene antibiotics ciprofloxacin, levofloxacin, ofloxacin Tetracycline antibiotics doxycycline Penicillin antibiotics amoxicillin, penicillin V, Penicillin G Vaccines are available six doses at 0, 2, and 4 weeks, then 6, 12, and 18 months, followed by annual boosters See Tierno 2002 or other medical references for details on administration of medications and/or vaccines... 

XR tabiets No dosage adjustment is required for patients with uncomplicated urinary tract infections receiving 500 mg ciprofloxacin XR. In patients with complicated urinary tract infections and acute uncomplicated pyelonephritis who have a Ccr of less than 30 mL/min, reduce the dose of XR tablets from... 

Equivalent AUC Dosing Regimens Ciprofloxacin oral dosage- Equivalent ciprofloxacin IV dosage... 

Gonococcal infections, uncomplicated 800 mg as a single dose (alternative regimen to ciprofloxacin or ofloxacin). 

Ciprofloxacin (Cipro, Cipro XR, Proquin XR) [Antibiotic/ Fluoroquinolone] Uses Rx lower resp tract, sinuses, skin skin structure, bone/joints, urinary tract Infxns including prostatitis Action Quinolone antibiotic DNA gyrase Dose Adults. 250-750 mg PO ql2h XR 500-1000 mg PO q24h or 200-400 mg IV ql2h in renal impair Caution [C, /-] Children <18 y Contra Component sensitivity Disp Tabs, susp, inj SE Restlessness, N/V/D, rash, ruptured tendons, T LFTs Interactions T Effects Wf probenecid T effects OF diazepam, theophylline, caffeine, metoprolol, propranolol, phenytoin, warfarin effects W/ antacids, didanosine, Fe salts. Mg, sucralfate, Na bicarbonate,... 

T Pancreatic insulin release Metformin Peripheral insulin sensitivity hepatic glucose output/production i intestinal glucose absorption Dose Ist-line (naive pts), 1.25/250 mg PO daily-bid 2nd-line, 2.5/500 mg or 5/500 mg bid (max 20/2000 mg) take w/ meals, slowly T dose hold before 48 h after ionic contrast media Caution [C, -] Contra SCr >1.4 mg/dL in females or >1.5 mg/dL in males hypoxemic conditions (sepsis, recent MI) alcoholism metabolic acidosis liver Dz Disp Tabs SE HA, hypoglycemia, lactic acidosis, anorexia, N/V, rash Additional Interactions T Effects W/ amiloride, ciprofloxacin cimetidine, digoxin, miconazole, morphine, nifedipine, procainamide, quinidine, quinine, ranitidine, triamterene,... 

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