Chromatographic and spectroscopic methods

Pan, L. et al. 2001. Comparison of chromatographic and spectroscopic methods used to rank compounds for aqueous solubility. J. Pharm. Sci. 90 521. 

Chromatography is a powerful, essential tool for the analysis of soils. Of the many forms of chromatography, gas and high-performance liquid chromatography are most commonly used in the analysis of soil extracts. Chromatographic and spectroscopic methods are almost exclusively referred to using... 

Prestera T, Fahey JW, Holtzclaw WD, Abeygunawardana C, Kachinski JL, Talalay P (1996) Comprehensive chromatographic and spectroscopic methods for the separation and identification of intact glucosinolates. Anal Biochem 239 168-179... 

IDENTIFICATION OF NATURAL PRODUCTS BY CHROMATOGRAPHIC AND SPECTROSCOPIC METHODS... 

Poole, C.R, Chromatographic and spectroscopic methods for the determination of solvent properties of room temperature ionic liquids, /. Chromatogr. A, 1037, 49-82, 2004. 

The final assessment of the purity of a known product is made on the basis of its physical constants (Sections 2.33 to 2.37 and Chapter 3) in comparison with those cited in the literature. In the case of a new compound the purity should be assessed and the structural identity established by appropriate chromatographic and spectroscopic methods. 

Andrikopoulos, N.K. 2002. Chromatographic and spectroscopic methods in the analysis of triacylglycerol species and regiospecific isomers of oils and fats. Crit. Rev. Food Sci. Nutr. 42, 473-505. 

Lunn G, Schmuff NR (1997) HPLC Methods for Pharmaceutical Analysis. Wiley-Intersciences, New York Pan L, Ho Q, Tsutsui K et al. (2001) Comparison of chromatographic and spectroscopic methods used to rank compounds for aqueous solubility. I Pharm Sci 90(4) 521-529 PSOL (PION) http //www.pion-inc.com/pSOL.htm Silveston R, Kronberg B (1994) Accurate measurements of solubility and thermodynamic transfer quantities using reversed-phase liquid-liquid chromatography. I Chrom 659(l) 43-56... 

In addition to the chromatographic and spectroscopic methods, sensitive color reactions are in many cases very useful for the specific identification of various natural dyes (30-33) or for recognizing individual dye classes (34, 35). In testing very old dyes, these reactions are sometimes able to yield results when most of the dye has already been destroyed by the action of light and all other identification methods fail. 

An important reagent in fluorous chemistry is the fluorous version of the Marshall resin, dubbed FluoMar (4). This separation tag is reported to dissolve readily in dichloromethane, tetrahydrofuran, and ethyl acetate and can, as many other fluorous reagents, be monitored by traditional chromatographic and spectroscopic methods. The usefulness of (4) was demonstrated in a multistep parallel synthesis of a 3 X 3 array of diamides, where the final products were efficiently purified by F-SPE and cleaved from the FluoMar tag. Tentative results indicated that the homogeneous kinetics of the soluble (4) resulted in reactions that proceeded approximately three times faster than polymer-support bound reactions using standard Marshall resin. 

Analytical techniques play a critical role in drug discovery by providing valuable information to control the identity, purity, and stability of potential drug candidates. These techniques, commonly in the form of chromatographic and spectroscopic methods, are routinely used in the pharmaceutical laboratory from the initial synthesis of a new chemical entity all the way through the development cycle to the manufacture and sale of a pharmaceutical product. 

Pan L, Ho Q, Tsutsui K, and Takahashi L. Comparison of Chromatographic and Spectroscopic Methods used to Rank Compounds for Aqueous Solubility, J Pharm Sci 2001 90 521-529. 

Morel G, Samhan 0, Literathy P. et al. 1991. Evaluation of chromatographic and spectroscopic methods for the analysis of petroleum-derived compounds in the environment. Fresenius J Anal Chem 339(10) 699-715. 

Therefore, UV-spectra ( CD-Value ) were used to distinguish between cold-pressed and distilled oil qualities. Today, a combination of modern chromatographic and spectroscopic methods is used to detect adulterations [357c -f]... 

U. dasyoneura Korth.). The chromatographic and spectroscopic methods used in this extensive screening programme, and the behaviour of over 60 indole alkaloids found in the Uncaria genus on which this identification is based, have been thoroughly discussed. ... 

Pharmaceuticals and related drugs Chemometrics/robotics, chromatographic and spectroscopic methods... 

The synthesis of these isomers was guided by a strategy of using only stereochemically pure phosphonium salts and polyene aldehydes as intermediates. To show the importance of various chromatographic and spectroscopic methods for the analysis of such intermediates, the preparation of the (7Z)-isomer of lycopene (31), is briefly considered in Scheme 5. This isomer is a major component of the mixture of (all- )-, (7Z)- and (7Z,7 Z)-lycopene formed in the Wittig reaction of geranyltriphenylphosphonium bromide with crocetindialdehyde [10] in the presence of NaOMe in dichloromethane [18]. 

Poole CF (2004) Chromatographic and spectroscopic methods for the determination of solvent properties of... 

Recent decades have witnessed significant advances in the efficiency and productivity of instrumental methods in the field of organic trace analysis. Chromatographic and spectroscopic methods in particular have improved greatly with respect to sensitivity. There has also been constant improvement in selectivity, to the point where some samples can now be subjected to analysis without prior preparation, although this is certainly not true in the majority of cases. The goal of sample preparation in organic trace analysis is to isolate the analyte from the sample matrix and then concentrate it and convert it into a form suitable for analysis by the selected method. 

A polarographic method for the determination of (96) has appeared [191] and chromatographic and spectroscopic methods to determine the purity of solutions of AC-17 (97) have been reported [192]. 

The use of combined instrumental techniques is increasing as equipment design improves and interpretation of the data extracted becomes easier. The application of simultaneons DSC-TGA with snbseqnent analysis by advanced chromatographic and spectroscopic methods greatly facilitates interpretation of data. Transfer of evolved gas from the furnace to a gas chromatograph coupled to a mass spectrometer provides additional information that may help researchers to understand the roles that individual compounds play within the relatively complex matrices of synthetic and natural fibers. The information extracted from these experiments can be particularly relevant, for example in studies of flame resistant additives in military fabrics (Yip, 2014). 

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