3-chloropropane-l,2-diol

From Allyl Alcohol. The reaction of allyl alcohol [107-18-6] with chlorine and water gives a mixture of glycerol m on ochl orohydrin s consisting of 73% 3-chloropropane-l,2-diol and 27% of 2-chloropropane-l,3-diol (57). In a recycle reaction system in which allyl alcohol is fed as a 4.5—5.5 wt % solution, chlorine is added at a rate of 7—9 moles per hour. The reaction time is about five seconds, the reaction temperature 50—60°C and the recycle ratio is 10—20 1. Under these conditions m on ochl orohydrin s have been obtained in 88% yield with 9% dichlorohydrins (58) (see Allyl ALCOHOL AND DERIVATIVES). 

Guaiphenesin Guaiphenesin, 3-(o-methoxyphenoxy)-l,2-propandiol (23.2.3), is synthesized by reacting guiacol with 3-chloropropan-l,2-diol or with glycidol [5-10],... 

Ch1oropheny11 r i methy1ammon i urn chloride, AP8U Chloropicrin, AAO3 3-Chloropropane-l,2-diol dinitrate, AB6U... 

Chloropropanediol and Derivatives Chloropropanediol, Chlorohydrin or Glyceryl Qilorohydrin(Called Chlorpropandiol, Mono-chlorhydrin, Glycerinchlorhydrin or Chlor-propyl englykol in Ger), CI.C3Hs(OH)2 mw 110.5 4. Two isomers are known, both of which are present in the commercial product 3-Chloropropane-l,2-diol or a-Chlorohydrin, Cl.CH2.CH(OH).CH2.OH, col to pale-yel si viscous liq having a pleasant odor, bp 213°... 

Ammonia Nitrogen (NH3-N) Not more than 1.5%. 3-Chloropropane-l,2-diol (3-CPD) Not more than 1 mg/ kg-... 

CPD Stock Solution Transfer 12.5 mg of reagent-grade 3-chloropropane-l,2-diol (3-CPD), accurately weighed, into a 100-mL volumetric flask, dilute to volume with ethyl acetate, and mix. 

CHLOROPROPANE-l,2-DIOL see CDT750 3-CHLORO-l,2-PROPANEDIOL see CDT750 CHLOROPROPANEDIOL CYCUC SULFITE see CKQ750... 

The same product (17) can be prepared from 3-chloropropan-l,2-diol.78... 

It may be prepared by the condensation of sodium-o-cresolate with 3-chloropropane-l, 2-diol and the resulting product is recrystallized from alcohol. 

Studies with the male antifertility agents 3-chloropropane-l,2-diol and 3-amino-l-chloropropane-2-ol have indicated that the antifertility activity in rat is due to the 5-enantiomers, whereas the i -enantiomers are associated with nephrotoxicity [160,161]. Metabolic studies indicated that a common metabolite was the causative agent, which was postulated to be (i )-3-chlorolactate. Administration of the enantiomers of 3-chlorolactate to rats resulted in elevated urinary excretion of oxalate, presumably formed via oxidation of the intermediate 3-chloropyruvate, a known inhibitor of renal... 

Synthesis of a vinyl cyclic acetal monomer is similar to the synthesis of a NVGA but includes a dehydrohalogenation step as shown in Figure 4. Stoichiometric amounts of the appropriate aryl aldehyde and 3-chloropropane-l,2-diol were reacted and worked up as previously described. The chloromethyl cyclic acetal intermediate was dissolved in toluene and added slowly to three equivalents of potassium rm-butoxide in toluene in a round bottom flask cooled in an ice bath. When the addition was complete, the mixture was allowed to warm to room temperature and stirred vigorously overnight. The dark reaction mixture was vacuum filtered through a paper filter covered with a small amount of silica gel. The filtrate was dried and concentrated as before. 

Glycidol fatty acid esters and 3-chloropropane-l,2-diol fatty acid esters... 

Chlorohydrin klor-o- hl-dron, kl6r- [ISV chlor- + hydr- + -in] (ca. 1890) (a-chloro-hydrin, 3-chloropropane-l,2-diol, glyceryl... 

First hints on the stereoselectivity of halohydrin dehalogenases were obtained from studies on the desymmetrization of prochiral 1,3-dichloropropan-2-ol yielding epichlorohydrin using resting cells of Corynebacterium sp. (Scheme 2.235) [1836]. In two-step sequence, (/ )-3-chloropropane-l,2-diol was formed in 74% e.e. via epichlorohydrin through the sequential action of an (unspecified) halohydrin de-halogenase and an epoxide hydrolase [1837]. Further studies revealed that these activities are widespread among bacteria [1838-1842]. 

C3H7CIO2 96-24-2 3-Chloropropan-l,2-diol syn. n.alpha.-Glycerol chlorohydrinn3-Chloro-1,2-propanediol... 

C3H7CIO2 96-24-2. alpha.-Glycerol chlorohydrin see 3-Chloropropan-l,2-diol... 

Chloropropanols (chlorinated propanols) are a group of three-carbon alcohols and diols with one or two chlorine atoms, which are hypothetically derived from glycerol. Six compounds, one chloro-propanol (3-chloropropan-l-ol, 12-22), two dichloropropanols (l,3-dichloropropan-2-ol, for short 1,3-DCP, 12-23 and 2,3-dichloropropan-l-ol, 2,3-DCP, 12-24), two chloropropanediols (3-chloropropane-l,2-diol, 3-CPD, also known as 3-MCPD from 3-monochloropropane-l,2-diol, 12-25, and 2-chloropropane-... 

CPD and 2,3-DCP are chiral compounds, which occur in protein hydrolysates and foods as racemic mixtines of corresponding enantiomers (-)-(J )-3-chloropropane-l,2-diol (12-28), (-F)-(S)-3-chloropropane-l,2-diol (12-29), (i )-2,3-dichloropropan-l-ol (12-30) and (S)-2,3-dichloropropan-l-ol (12-31), respectively. 

Hamlet C.G., Asuncion L., Velisek J., Dolezal M., Zelinkovi Z., Crews C. Formation and occurrence of esters of 3-chloropropane-l,2-diol (3-CPD) in foods What we know and what we assume. European Journal of Lipid Science and Technology, 113 279-303 (2011). 

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