Antifertility activity

Dithiazolones, chloro-chlorination, 6, 915 Dithiazolylium salts antifertility activity, 6, 944 as chemosterilants, 6, 944 as herbicides, 6, 944 IR spectra, 6, 907 reduction, 6, 918 Dithiazolylium salts, amino-reactions... 

The roots of Aristolochia indica, commonly known as an Indian birthwort, are reputedly used in Indian folk medicine as an emmenagogue and as an abor-tifacient. Aristolochic acid and its methyl ester, sesquiterpene (12S)-7,12-secoishwaran-12-ol, isolated from this plant, possessed significant antifertility activity in mice (103-105). 

Prakash, A. O., and R. Mathur. Screening of Indian plants for antifertility activity. Indian J Exp Biol 1976 14 623-626. 

Condensation (dioxan + cone. HC1) of p-benzyloxy benzoin with various phenols or naphthols gives 3-(p-benzyloxyphenyl)-2-phenyl-benzofurans, starting material for the preparation of diarylbenzofurans and of 1,2-diphenylnaphtho[2,1 -6]furans with antifertility activity.83... 

When several diterpenoids and triterpenoids, isolated from the herb, were examined for antifertility activity, 1 showed the most potent in vitro spermicidal activity [99]. In contrast, 4 had the most potent male in vivo antifertility effect in the modified MB-50 assay, and it was therefore suggested that 4 might be a good candidate to be developed into a male antifertility agent. 

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