Chloro-m-cresol

Synonyms PCMC 4-chloro- -cresol 3-methyl-4-chlorophenol Candaseptic Preven-tol CMK 

Occular irritation has been reported in rabbits at concentrations as low as 0.05%. Some evidence of dermal irritation and sensitization has been reported in animal and human studies.  

A threshold limit value has not been assigned to PCMC. 

Toxicology. p-Chloro-m-cresol (PCMC) causes kidney damage in male rats after chronic exposure. 

Bayer AG Initial Submission chronic toxicity and carcinogenicity study in Wistar rats (administration in feed for 104 weeks) (Interim Report) with cover letter dated 3/27/92, TSCATS/422992, EPA/OTS Doc 88-920001578 

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Chlorodane, technical Chlorobenzene 4-Chloro-m-cresol Chloroform... 

In accordance with the pharmacogenetic nature of MH, pharmacological activators of RyRl Ca2+ release such as caffeine, halothane, or 4-chloro-m-cresol induce contractures at lower concentrations in MH muscle than in normal muscle when studied in vitro. This differential susceptibility forms the basis of the in vitro contracture test (IVCT) used in the determination of MH susceptibility (1984 Larach 1989 Rosenberg 2002). 

Chloro-m-cresol p-Chloro-TO-xylenol 6-Amino-m-cresol68... 

Chemical Name 4-chloro-m-cresol, 4-chloro-3-methylphenol... 

Aptal Baktol 4-chloro-m-cresol p-chloro-m-cresol 1-chloro-4-hydroxy-2-methylbenzene 2-chloro-5-hydroxytoluene 6-chloro-3-hydroxytoluene 4-chloro-3-methylphenol 3-methyl-4-chlorophenol Nipacide PC parachlorometacresol PCMC. 

CHLORO-m-CRESOL (59-50-7) Combustible solid (flash point 244°F/118°C). Incompatible with strong oxidizers and sodium hydroxide. Attacks active metals, aluminum, copper, etc. Flow or agitation of substance may generate electrostatic charges due to low conductivity. 

U039. . 4-Chloro-m-cresol U061 Dichloro diphenyl trichloroethane... 

Chlorocresol 4-Chloro-m-cresol p-Chlorocresol. Seep-Chloro-m-cresol p-Chloro-m-cresol... 

Synonyms p-Chlor-m-cresol Chlorocresol 4-Chloro-m-cresol p-Chlorocresol 2-Chlorohydroxytoluene 2-Chloro-5-hydroxytoluene 4-Chloro-3-methylphenol 3-Methyl-4-chlorophenol Parachlorometacresol PCMC Classification Substituted phenol Empirical C7H7CIO... 

Normally water-insoluble drugs with a phenyl ring can form molecular complexes with surfactants. The chemical structures of l-(2,4,6-trihydroxyphenyl)-l-propanone (flopro-pione), an anti-spasmodic, and 4-chloro-m-cresol (a germicide) are shown in Figure 4.34. They became soluble in aqueous solutions in the presence of surfactants, probably because of complex formation. In order to understand the nature of complex formation, the cationic surfactants CTAB and MTAB were used. The complex crystals between CTAB and 4-chrolo-m-cresol (XXIII), MTAB and flopropione (XXIV), and CTAB and flopropione (XXV) were obtained from the solutions of methanol, methanol and aqueous solutions, respectively. 

The crystal structure of the complex XXIII viewed along the a-axis is shown in Figure 4.35. The alkyl groups of the CTA cations with an all trans conformation are arranged in an anti-parallel way along the ft-axis. The interaction between the cation and 4-chloro-m-cresol is essentially the same as that of the common packing pattern observed above. The 4-chloro-m-cresol molecule is sandwiched by the alkyl groups of the CTA cations. 

Figure 4.34 Structural formulae of flopropione and 4-chloro-m-cresol...

Figure 4.39 Molar loss of 4-chloro-m-cresol with increasing temperature in the crystals of 4-chloro-m-cresol only (A) and its complexes with CTAB (O), MTAB (o) and LTAB (x). Reprinted from [78] with permission from The Chemical Society of Japan. Copyright 1999...

N-(3-Chloroallyl) hexaminium chloride 1-(3-Chloroallyl)-3,5,7-triaza-1-azoniaad-amantane chloride. See Quaternium-15 Chlorocresol 4-Chloro-m-cresol p-Chlorocresol. See p-Chloro-m-cresol p-Chloro-m-cresol... 

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