Chloramine-T-Sodium iodide

Chloramine-T-Sodium iodide, 70 Iodine-Trimethylsilyl chlorochromate, 327... 

Sodium hydrogen sulfide, 487 Sodium hydrogen sulfite, 487 Sodium hypochlorite, 487-488 Sodium iodide-Chloramine-T, 488-489 Sodium iodide-Pivaloyl chloride, 489 Sodium methoxide, 489 Sodium methylsulfinylmethylide, 489-490 Sodium naphthalenide, 490-491 Sodium nitrite, 491... 

Radioiodination of galactose oxidase. The chloramine T procedure (12) was used for the radioiodination of galactose oxidase. The enzyme, solubilized in 0.01 M sodium phosphate buffer, pH 7.4, was labeled using 1 mCi Na 125I (13-17 mCi/ngl), 0.42 mM chloramine T (Eastman), and 1.14 mM sodium metabisulfite (Baker). Unreacted iodide was separated from the iodination enzyme by dialysis, and the enzyme was diluted in 0.1 M sodium phosphate buffer, pH 7.4, containing 0.001 M cupric sulfate. 

Butyl-4(5)-[125I]iodo-5(4)-hydroxymethylene imidazole 349 has been prepared330 by treatment of 350 with chloramine T in the presence of [x 2 5I]sodium iodide (equation 149). The product 349 isolated by HPLC is obtained in chemical and radiochemical yields of 70% at specific activity equal to 2200 Ci mmol -1. 

Sodium iodide and chloramine-T can be used for the production of iodides, a process that has particular application to the introduction of radioactive iodine. ... 

An aqueous solution of di(triethylamonium) dodecahydro-ctoio-dodecaborate(2-), (EtjNH)2Bl2H12, (10 pi, lmg/ml) and an astatine solution in methanol (5 pi) were added to 30 pi of buffer solution (pH 7.5). Labelling was started by addition of 10 pi of solution of the sodium salt of A chloro-p-toluenesulfonamide, Chloramine T, (5 mg/ml in water). The mixture was vortexed for a few seconds and left to react for 5 min. The reaction was quenched with 20 pi of solution of sodium metabisulfite, Na Oj, (4 mg/ml in water). Sodium iodide, Nal, (5 pi, 20 mg/ml in water) was added as carrier before analysis. 

Perform the reaction in a well-ventilated fume-chamber in an ice-water bath. Use a micropipette to add 2 mCi of I (10 pi) to 10 pi of anti-IgE (10 pg) in a 55 X 12 mm polystyrene tube and then in quick succession, with rota-mixing, add 10 pi of chloramine-T (20 pg), 10 pi of sodium metabisulfite (40 /ag), and 1 ml of albumin buffer. Separate the radiolabeled anti-IgE from denatured products and free iodide by filtration through Sephadex G-200 with albumin buffer. Store at 4°. 

Another effective iodination method is the treatment of thienotrifluoroborates and ben-zothienotrifluoroborates with sodium iodide and an oxidant [32], Thus, 3-thienotrifluo-roborate 23 and 2-benzothienotrifluoroborate 25, derived from their corresponding boronic acids, were converted to their iodo adducts 24 and 26 in the presence of sodium iodide and chloramine-T in aqueous THF in 83 and 72% yields, respectively. Other oxidants such as w-CPBA and hydrogen peroxide delivered the predicted products however, the yields were significantly lower. 

The oxidation can be carried out in acidic, neutral, or basic media. Iodide will be oxidized to iodine in basic and neutral media and to iodine monochloride in acidic medium (HCl). In aqueous solution, chloramine T forms hypochlorous acid (HOCl), which is thought to be the actual oxidizing species. The oxidation can be controlled by the depletion of chloramine T, as the fimiting reagent or by the addition of a reducing agent (sodium bisulfite) to stop it (Robles et al, 2001). 

Chemical Properties of Thiazolidines.—Alkylation of metal salts of thiazolidine-2-thione can yield either TV-alkyl derivatives, depending on the type of solvent, the alkylating agent, and the counter-ion e.g., the sodium salt with methyl iodide in dioxan gives mainly the 5-methyl compound, whilst with dimethyl sulphate in DMSO the N-methyl derivative is obtained. Oxidative imination of the thiazolidin-4-one (82), using Chloramine-T, gives (83) quantitatively, whilst... 

Kometani, T., et al. (1985a). Iodination of Phenols Using Chloramine-T and Sodium Iodide, Tetrahedron Letters 26 2043-2046. 

Chloramine-T m-Cresyl acetate D C Red No. 6 D C Red No. 7 Dichlorobenzyl alcohol Hexamidine diisethionate Mercury chloride (ic) Phenethyl alcohol Phenylmercuric borate Resorcinol Zinc carbonate Zinc peroxide antiseptic, topical anti-infectives Cetearyl alcohol Jsopropyl alcohol Sodium iodide... 

Dioctyl dimonium chloride sanitizer, food-contact Acetic acid Benzalkonium chloride Calcium hypochlorite Chloramine-T Dichloroisocyanuric acid Etidronic acid Lithium hypochlorite Potassium dichloroisocyanurate Potassium hypochlorite Potassium iodide Potassium permanganate Quaternium-24 Sodium dichloroisocyanurate Sodium dodecylbenzenesulfonate Sodium hypochlorite... 

Direct radioiodination with Chloramine-T, Chloramine-T solution (50 fily 1 mgmlT ) was added to a mixture of BZM (50 ///, 1 mg ml )y sodium I]iodide (10 fily 37-185 MBq [1-5... 

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