Chitosans nerve regeneration

Wang W et al (2009) Effects of Schwann cell alignment along the oriented electrospun chitosan nanofibers on nerve regeneration. J Biomed Mater Res A 91A(4) 994-1005... 

Zheng L, Ao Q et al (2010) Evaluation of the chitosan/glycerol-beta-phosphate disodium salt hydrogel application in peripheral nerve regeneration. Biomed Mater 5 35003... 

Ishikawa N, Suzuki Y, Ohta M et al (2007) Peripheral nerve regeneration through the space formed by a chitosan gel sponge. J Biomed Mater Res 83A 33 0... 

Zhang, Z., Wang, S., Tian, X., Zhao, Z., Zhang, J., Lv, D. A new effective scaffold to facilitate peripheral nerve regeneration Chitosan tube coated with maggot homogenate product. Medical Hypotheses. 2010, 74, 12-14. 

J. Tanaka, Effects of a laminin peptide (YIGSR) immobilized on crab-tendon chitosan tubes on nerve regeneration, J. Biomed. Mater. Res. B Appl. Biomater. 73 (2005) 375-382. 

K. Shinomiya, et al.. Tendon chitosan tubes covalently coupled with synthesized laminin peptides facilitate nerve regeneration in vivo, J. Neurosci. Res. 72 (2003) 646-659. 

A. Wang, Q. Ao, Y. Wei, K. Gong, X. Liu, N. Zhao, et al.. Physical properties and biocompatibility of a porous chitosan-based fiber-reinforced conduit for nerve regeneration, Biotechnol. Lett. 29 (2007) 1697-1702. 

The high extent of axonal regeneration in the investigated crushed sciatic nerves, which have been contacted by such lyophilized chitosan membranes, indicates that chitosan acts as an inducer of nerve regeneration rather than just as a scaffold providing mechanical stabilization. The authors speculated that chitosan in these materials enhances Schwann cell proliferation, axon elongation and myelination. Additionally, silica ions may influence the... 

New nerve regeneration strategy combining laminin-coated chitosan conduits and stem cell therapy. Acta Biomater. 9, 6606-6615. 

Nerve conduit should be resistant to compression too. Stmctures that promote nerve regeneration in nerve gap repair by implantation of substitute, like chitosan porous stmcture, usually have low mechanical strength under physiological conditions. Handling these is very challenging, and risk of implanted stmcture/budding nerve cells... 

Xu G, et al. Optic nerve regeneration in polyglycolic acid-chitosan conduits coated with recombinant Ll-Fc. Neuroreport 2004 15(14) 2167—72. 

Yamaguchi, I., Itoh, S., Suzuki, M.,etal. (2003) The chitosan prepared from crab tendons II. The chitosan/apatite composites and their application to nerve regeneration. Biomaterials, 24,... 

Pluronic has been extensively used in the pharmaceutical industry as a carrier for the controlled release of drugs (Kabanov et al, 2002). A copolymer of Pluronic with chitosan was developed as an injectable cell delivery carrier for cartilage regeneration (Park et al, 2009). The efficacy of poly(lactic-co-glycolic add)/F127 nerve guidance channels has also been demonstrated in an animal trial the results showed enhanced nerve regeneration associated with the use of this material (Oh et al, 2008). 

Ao Q, Fung CK, Tsui AY et al (2011) The regeneration of transected sciatic nerves of adult rats using chitosan nerve conduits seeded with bone marrow stromal cell-derived Schwatm cells. Biomaterials 32 787-796... 

Wang X, Hu W, Cao Y et al (2005) Dog sciatic nerve regeneration across a 30-mm defect bridged by a chitosan/PGA artificial ntave graft. Brain 128 1897-1910... 

Chitosan TFA-MC Effects of mechanical strength and permeability of fiber mats on nerve regeneration. [194]... 

Wang, W., et al. (2008). Influences of mechanical properties and permeability on chitosan nano/microfiber mesh tubes as a scaffold for nerve regeneration. Journal of Biomedical Materials Research Part A, 84A(2), 557-566. 

Keywords Chitosan Nanoparticles Microspheres Chemically modified chitosans Polyelectrolyte complexes Oral and nasal administration Nerve, cartilage and bone regeneration Wound dressing... 

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