Chitosan microcapsules

El-Gibaly, I. 2002. Development and in vitro evaluation of novel floating chitosan microcapsules for oral use comparison with non-floating chitosan microspheres, Int J Pharm 249 7. 

K. Aiedeh, E. Gianas, I. Orienti, V. Zecchi, Chitosan microcapsules as controlled release systems for insulin, J. Microencapsulation 14 567-576 (1997). 

Lin, S. Y. and Lin, P. C. Effect of acid type, acetic acid and sodium carboxymethylcellulose concentrations on the formation, micromeretic, dissolution and floating properties of theophylline chitosan microcapsules. Chem. Pharm. Bull. 40 (1992) 2491-2497. 

Urbanska, A.M., Bhathena, J., and Prakash, S. 2007. Live encapsulated Lactobacillus acidophilus cells in yogurt for therapeutic oral delivery Preparation and in vitro analysis of alginate-chitosan microcapsules. Can. J. Physiol. Pharmacol. 85 884—893. 

Lam, P.-L. et al.. Development of hydrocortisone succinic acid/and 5-fluorouracil/chitosan microcapsules for oral and topical drug deliveries. Bioorganic and Medicinal Chemistry Letters, 2012. 22(9) 3213-3218. 

Genta, I., Perugini, P., Modena, T., Pavanetto, R, Castelli, R, Muzzarelli, R.A.A., Muzzarelli, C., Conti, B. Miconazole-loaded 6-oxychitin-chitosan microcapsules. Carbohydr. Polym. 2003, 52 (1), 11-18. 

J. Adamiec and Z. Modrzejewska, Spray-dried chitosan microcapsules. Proceedings of 11th Intematiorud Workshop on Bioencapsulation, 25-27 May, Strasbourg, France, D. Poncelet (Ed.), p. 10 (2003). 

FIGURE 30.2 The scheme of animal cell bioencapsulation in alginate-chitosan microcapsules. 

FIGURE 30.3 In vitro cultivation of endostatin-transfected CHO cells in alginate chitosan microcapsules (a) just after encapsulation, (b) day 5, (c) day 12, and (d) day 21. 

To accelerate healing of 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats, chitosan microcapsules loaded with the anti-inflammatory drug, 5-aminosalycylic acid (5-ASA), have been evaluated in Japan [41]. In conclusion, several research groups deal with development of chit-osan-based microparticles with entrapped insulin as peroral delivery systems [42,43]. 

Figure 5.9 SEM micrographs of the cellulose textile linked to chitosan microcapsules containing grapefruit seed extract (Alonso et al., 2010).

Biopolymers have always been attractive materials in a variety of biomedical appU-cations including transdennal drug deUvery (Petrasic, 2011). Chitosan, a readily available biodegradable and biocompatible biopolymer, has been successfully used in fabrication of microcapsules intended for oral or topical medications. In a smdy of Lam et al., 5-fluoromucil was encapsulated in chitosan microcapsules and subsequently applied to a cotton fabric to a create transdennal delivery vehicle (Lam et al., 2012) 5-fluorouraciI (5-fluoro-lH-pyrimidine-2,4-dione) was chosen for its effective cytotoxic activity in the topical treatment of various forms of skin cancers. It was dissolved in calendula-infused oil and the mixture was then dispersed in the chitosan solution (in acetic acid) and stined into an emulsion. Sodium hydroxide... 

I. El-Gibaly, A.M. Meki, and S.K. Abdel-Ghaffar, Novel B melatonin-loaded chitosan microcapsules In vitro characterization and antiapoptosis efficacy for aflatoxin Bl-induced apoptosis in rat liver, Int. J. Pharm., 260 (1), 5-22, 2003. 

Rutin alginate chitosan microcapsules Rutin Targeting into cardio-cascular and cerebrovascular region Cardiovascular and Cerebrovascular diseases... 

L. Xiao, YH. Zhang, J.C. Xu, X.H. Jin, Preparation of floating rutin-alginate-chitosan microcapsule, Chine. Trad. Herb. Drugs, 2 209-212, 2006. 

The major advantage of enzyme responsive polymers is that they do not require an external trigger. For instance, polymer systems based on alginate/chitosan or DEXS/chitosan microcapsules are responsive to chitosanase [126]. On the other hand, azo-aromatic bonds are sensitive to azo-reductase [127]. These enzymes, naturally produced by bacteria principally located in the colon, are capable of degrading polysaccharides like pectin, chitosan, amylase/amylopectin, cyclodex-trin and dextrin [120,125, 165]. 

Li S, Wang X, Zhang X, Yang R, Zhang H, Zhub L, Houa X. (2002). Studies on alginate-chitosan microcapsules and renal arterial embolization in rabbits./ Control Release, 84,87-98. 

Volatile citronella essential oil c/-Limonene Citronellal chitosan microcapsules bug repellent, deodorizing [16]... 

---