Alginate-chitosan microcapsules

Urbanska, A.M., Bhathena, J., and Prakash, S. 2007. Live encapsulated Lactobacillus acidophilus cells in yogurt for therapeutic oral delivery Preparation and in vitro analysis of alginate-chitosan microcapsules. Can. J. Physiol. Pharmacol. 85 884—893. 

FIGURE 30.2 The scheme of animal cell bioencapsulation in alginate-chitosan microcapsules. 

FIGURE 30.3 In vitro cultivation of endostatin-transfected CHO cells in alginate chitosan microcapsules (a) just after encapsulation, (b) day 5, (c) day 12, and (d) day 21. 

Rutin alginate chitosan microcapsules Rutin Targeting into cardio-cascular and cerebrovascular region Cardiovascular and Cerebrovascular diseases... 

L. Xiao, YH. Zhang, J.C. Xu, X.H. Jin, Preparation of floating rutin-alginate-chitosan microcapsule, Chine. Trad. Herb. Drugs, 2 209-212, 2006. 

Li S, Wang X, Zhang X, Yang R, Zhang H, Zhub L, Houa X. (2002). Studies on alginate-chitosan microcapsules and renal arterial embolization in rabbits./ Control Release, 84,87-98. 

Gaserod, O., Smidsrod, O. and Skjak-Braek, G., Microcapsules of alginate-chitosan—1. A quantitative study of the interaction between alginate and chitosan, Biomaterials, 19, 1815, 1998. 

Wen-tao, Q., Wei-ting, Y., Yu-bing, X., Xiaojun, M., 2005. Optimization of Saccaromyces cerevisiae culture in alginate-chitosan-alginate microcapsule. Biochemical Engineering Journal 25 (2), 151-157. 

FIGURE 33.4 Dynamics of bacterial cell density (log x cfu/mL) at different periods (30, 60, 90, and 120 min) after successive incubation of chitosan-coated alginate (AG) microcapsules containing L. plantarum ATCC 8014 (AG 1% CH, AG 1.5% CH, and AG 2% CH) in simulated gastric juice (pH 1.5) for 60 min and in simulated intestinal juice at 37°C for 2 h. The decimal reduction time values D (min) are represented for each variant. 

Taqieddin E., Amiji M., Enzyme immobilization in novel alginate-chitosan core-shell microcapsules. Biomaterials, 25(10), 2004, 1937-1945. 

Another medical appUcalion of biopolymer-based microcapsules was reported by Hui et al. (2013). It was shown that a cotton fabric with embedded chitosan-sodium alginate (CSA) microcapsules loaded with traditional Chinese herbs, PentaHerbs, could be potentially used in the treatment of atopic dermatitis. The active ingredient used was gallic acid. The drug release from the chitosan-sodium alginate microcapsule was tested in vitro, under two simulated human skin conditions, in phosphate buffer saline (PBS) of pH 5.4 and 5.0. Fig. 5.12 demonstrates the fast release of gallic acid... 

Figure 5.12 Release profiles of gallic acid from chitosan-sodium alginate (CSA) microcapsules immersed in phosphate buffer saline (PBS) of pH 5.0 and pH 5.4.

Microcapsules of alginate/chitosan containing magnetic NPs For controlled release of insulin [218]... 

Recent research has explored various chitosan based microencapsulated nanoparticles for circumventing various problems of conventional delivery systems. One beautiful example of chitosan-alginate PEC microcapsules by membrane emulsification method is mentioned in Fig. 3.10. 

Fig. 3.10 Plan representation of chitosan-alginate PEC microcapsules by membrane emulsification method...

FinoteUi PV, SUva DD, Sola-Penna M, Rossi AM, Farina M, Andrade Leonardo R, Takeuchi AY, Rocha-Leao MH. Microcapsules of alginate/chitosan containing magnetic nanoparticles for controlled release of insuUn. Colloids Surf B Biointerfaces. 2010 81(1) 206-11. 

The major advantage of enzyme responsive polymers is that they do not require an external trigger. For instance, polymer systems based on alginate/chitosan or DEXS/chitosan microcapsules are responsive to chitosanase [126]. On the other hand, azo-aromatic bonds are sensitive to azo-reductase [127]. These enzymes, naturally produced by bacteria principally located in the colon, are capable of degrading polysaccharides like pectin, chitosan, amylase/amylopectin, cyclodex-trin and dextrin [120,125, 165]. 

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