Chitosan glycosaminoglycans

This chapter will give you an overview of recent approaches for drug development, focusing on the function and roles of carbohydrates. O Section 2 will outline the biochemical functions of polysaccharide (neutral polysaccharide, chitin and chitosan, glycosaminoglycan, and synthetic polysaccharides) and glycopolymers and the perspectives of their medicinal/medical use. O Section 3 will outline recent biopharmaceutical research and development, utilizing... 

Lee, J.E. et al.. Effects of the controlled-released TGF-bl from chitosan microspheres on chondrocytes cultured in a coUagen/chitosan/glycosaminoglycan scaffold. Biomaterials, 25, 4163, 2004. 

Scaffolds can be made from natural or synthetic materials. Such materials fall under the category of biomaterials. A biomaterial can be considered a single element or compound, which is a composite or mixture of elements, and is synthesized or derived to be used in the body to preserve, restore, or augment the structure or function of the body. Examples of natural materials for scaffold construction are extracellular matrix, collagen, fibrin, and polysaccharides (e.g., chitosan or glycosaminoglycans). Natural materials, unless they are obtained from the patient who receives the neo-organ implant, will cause an immunogenic response. This is not always the case with synthetic materials. 

Carrageenan Hyaluronic acid Heparin and heparin-like glycosaminoglycanes Dextran and derivatives Chitosan and derivatives... 

Chitosan is a linear randomly distributed, binary heteropolysaccharide prepared by deacetylation of chitin, a linear polymer of P(l-4) linked N-acetyl-o-glucosamine units composed of mucopolysaccharides and amino sugars. It is a natural poly-(aminosaccharide), having structural characteristics similar to glycosaminoglycans. 

Collagen-glycosaminoglycan, chitosan-linked Poly(lactide-glycolide)... 

Sheihabeddin L., Berthod F., Damour O., CoUombel C., Characterization of skin reconstructed on a chitosan-collagen-glycosaminoglycan matrix, S nPAarmoco/., 3, 1990, 107—114. 

Mammalian Polysaccharides Glycosaminoglycans (hyaluronic acid or hyaluronan, Chondroitin sulphate), gelatin and heparin sulfate, chitin and chitosan... 

Significant improvement of functional properties has been reported for fibers obtained from blends of chitin with various natural polymers such as cellulose, silk fibroin and glycosaminoglycans [48, 50, 51]. Fibers of chitosan blended with alginate, collagen and gelatin have been evaluated for wound dressing and artificial skin applications [52, 53, 108, 136]. 

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