Chiral separation with

Rawjee, Y.Y., Stark, D.U., Vigh, G. Capillary electrophoretic chiral separations with cyclodextrin additives I. acids Chiral selectivity as a function of pH and the concentration of P-cyclodextrin for fenoprofen and ibuprofen. J. Chromatogr. 1993, 635, 291-306. 

Matthijs, N., Perrin, C., Maftouh, M., Massart, D.L., Vander Heyden, Y. Knowledge-based system for method development of chiral separations with capillary electrophoresis using highly sulphated cyclodextrins. J. Pharm. Biomed. An. 2002, 27, 515-529. 

An overview of the principles of chiral separations in CE and HPLC is given in the first part of this chapter. The second part is dedicated to an overview of chiral separation with CE. The popularity of electrophoretic techniques has grown spectacularly in recent years, mainly due to their exceptional performances in the chiral field. Various selectors can easily... 

F Lelievre, P Gareil, A Jardy. Selectivity in capillary electrophoresis application to chiral separations with cyclodextrins. Anal Chem 69 385—392, 1997. 

F Lelievre, P Gareil, Y Bahaddi, H Galons. Intrinsic selectivity in capillary electrophoresis for chiral separations with dual cyclodextrin systems. Anal Chem 69 393-401, 1997. 

Since Pasteur separated crystalline sodium ammonium tartrate manually in 1848, many researchers have worked on the subject of enantiomeric separation. In 1939 Henderson and Rule fully separated derivatives of camphor by column chromatography using lactose as a stationary phase material [1]. Gil-Av et al. [2] were able to separate amino acid derivatives on a polysiloxane-based stationary phase by gas chromatography (GC) in 1966. Since then many approaches for a successful distinction between enantiomers have been developed for capillary GC and liquid chromatography [3]. It is still a current topic for researchers searching for chiral separation with SciFinder [4] results in 812 hits and searching for chiral recognition leads to 285 hits for the year 2003 only. 

H.T. K. Xuan and M. Lederer, Adsorption chromatography. IX. Chiral separation with aqueous solvents and liquid-liquid systems, J. Chromatogr. A. 635 (1993), 346. 

Huynh, T.K.X. Lederer, M. Adsorption chromatography on cellulose. XL Chiral separations with aqueous solutions of cyclodextrins as eluents. J. Chromatogr. 1994, 659, 191-197. 

Fig. 6.23 Chiral separations with identical separation factors (a) and different chiral resolutions (cRs) (From ref [11])...

Ning, J. G. Direct chiral separation with Chiral-palc AD converted into the reversed-phase mode,]. Chromatogr. A, 1998, 805(1-2), 309-314. 

Liu,Y., Berthod, A., Mitchell, C. R., Xiao,T. L., Zhang, B., Armstrong, D. W. Super/subcritical fluid chromatography chiral separations with macrocyclic glycopeptide stationary phases, J. Chromati. A, 2002, 978, 185-204. 

Liu Y, Berthod A, Mitchell CR, Xiao TL, Zhang B, Armstrong DW. Super/ subcritical fluid chromatography chiral separations with macrocyclic glycopep-tide stationary phases. J Chromatogr A 2002 978 185-204. 

F Wang, MG Khaledi. Non-aqueous capillary electrophoresis chiral separations with sulfated beta-cyclodextrins. J Chromatogr B 731 187-197, 1999. 

Tlie first chiral separation with open-tubular columns in SFC was published by Roder et al. in 1987 [39]. Schurig and co-workers [40] linked permethylated fi-CyD via an octamethylene spacer to polydimethylsiloxane forming a chiral polymer Chirasil-Dex. The polymer was immobilized on the inner surface of fused-silica capillaries and the capillaries were used for so-called unified chromatography including GC, LC, SFC, and capillary electrochromatography (CEC). 

D. Mangelings, M. Maftouh, Y. van der Heyden, Capillary electrochromatographic chiral separations with potential for... 

ISO standard 9842 shows character and data for oils from various sources. Blending is done with synthetic phenyl ethyl alcohol, synthetic rhodinol, and geraniol from palmarosa oil. Geranium oil, ylang oil, rose absolute, and palmarosa oil are used for nishing. Detection has to be done by GC MS system and by chiral separation with multidimensional GG-MS. Kreis and Mosandl (1992)... 

Simulated Moving Beds (SMBs) are well established for the adsorption based separation of hydrocarbons as well as of fine chemicals, particularly enantiomers. This technology covers a broad range of production scales from the laboratory units, which use chromatographic columns with a 0.5 cm internal diameter, to the mnlti-ton prodnction nnits licensed by Novasep for chiral separations with colnmn diameters between 20 and 100 cm, to the largest SMB unit licensed recently in South Korea by the Institute Francaise du Petrol with a column diameter of 8 m for the prodnction of 700,000 tons per year of p-xylene. New applications are envisaged in the near fntnre, particnlarly in the emerging area of bio-separations, e.g. for the pnrification of enzymes, peptides, antibiotics and natural extracts. 

Wang F, Khaledi M (1998) Nonaqueous capillary electrophoresis chiral separations with quaternary ammonium P-cyclodextrin. J Chromatogr A 817 121-128... 

Danger, G. Ross, D. Chiral separation with gradient elution isotachophoresis for future in situ extraterrestrial analysis. Electrophoresis 2008, 29, 4036 044. 

---