Chinese crude drug sang-Bai

Hano, Y. and Nomura T., Constituents of the Chinese crude drug Sang-bai-pi Morus root barks), IV. Structures of four new flavonoids, Sanggenon H, I, J and K, Heterocycles, 20, 1971, 1983. 

Hano, Y. et al., Sanggenons R, S and T, three new isoprenylated phenols from the Chinese crude drug Sang-Bai-Pi (Moms root bark). Heterocycles, 40, 953, 1995. 

About seventy kinds of new phenolic compounds could be isolated from Japanese cultivated mulberry tree (Morus alba, M. bombycis, and M, Ihou) and Chinese crude drug Sang-Bai-Pi (the root bark of Chinese mulberry tree). Most of them are isoprenylated flavonoids. Among them, kuwanon G (1) was the first isolation of the active substance exhibiting the hypotensive effect from the Japanese Morus alba root bark [9]. Furthermore, kuwanon G (1) and its isoprenylated derivative kuwanon H (2) [10] are considered to be formed through an enzymatic Diels-Alder type reaction of a chalcone and a dehydrokuwanon C or its... 

Hano, Y., H. Kohno, M. Itoh, and T. Nomura Constituents of the Cultivated Mulberry Tree XXIX. Constituents of the Chinese Crude Drug Sang-Bai-Pi Morns Root Bark) VII. Structures of Three New 2-Arylbenzofuran Derivatives from the Chinese Crude Drug Sang-Bai-Pi Moms Root Bark). Chem. Pharm. Bull. (Japan) 33, 5294 (1985). 

Nomura, T., T. Fukai, and Y. Hano Constituents of the Cultivated Mulberry Tree IX. Constituents of the Chinese Crude Drug Sang-Bai-Pi Morus Root Bark) I. Structure of a New Flavanone Derivative, Sanggenon A, Planta medica 47, 30 (1983). 

Fukai, T., Y. Hano, T. Fujimoto, and T. Nomura Structure of Sanggenon G, a New Diels-Alder Adduct from the Chinese Crude Drug Sang-Bai-Pi Morus Root Barks). Heterocycles 20, 611 (1983). 

Nomura T, Fukai T, Hano Y, Uzawa J 1981 Structure of sanggenon C, a natural hypotensive Diels-Alder adduct from Chinese crude drug sang-bai-pi (morus root barks). Heterocycles 16 2141-2148... 

On the other hand, in Japan, Sang-Bai-Pi (the root bark of Chinese mulberry tree) imported from China has been used as an herbal medicine, hence a study of the components of this crude drug purchased in the Japanese market was undertaken. Its phenolic components are different from those of Japanese mulberry tree. For example, morusin (3) and kuwanon G (1) are the main phenolic components of Japanese mulberry tree, in the case of Sang-Bai-Pi , these components are minor ones, while sanggenons A (4) [16], C (5) [17], and D (33) [61] are the main components [24]. Sanggenons C (5) and D (33) showed the hypotensive effects as follows Sanggenon C (5) caused transient decrease in arterial blood pressure at the doses of 1 mg/kg in pentobarbital-anesthetized rabbit by 15 mm Hg, while at the doses of 5 mg/kg the compound (5) caused a transient decrease by 100 mm Hg, which continued for more... 

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