Morus alba root bark

About seventy kinds of new phenolic compounds could be isolated from Japanese cultivated mulberry tree (Morus alba, M. bombycis, and M, Ihou) and Chinese crude drug Sang-Bai-Pi (the root bark of Chinese mulberry tree). Most of them are isoprenylated flavonoids. Among them, kuwanon G (1) was the first isolation of the active substance exhibiting the hypotensive effect from the Japanese Morus alba root bark [9]. Furthermore, kuwanon G (1) and its isoprenylated derivative kuwanon H (2) [10] are considered to be formed through an enzymatic Diels-Alder type reaction of a chalcone and a dehydrokuwanon C or its... 

As mentioned earlier, Deshpande et al had reported the isolation and structure determination of four flavones with isoprenoid substituents from Morus alba root bark, mulberrin (1), mulberrochro-mene (2), cyclomulberrin (3), and cyclomulberrochromene (4) (20). The difference between the flavones with isoprenoid substituents isolated by Deshpande et al. and those, such as morusin (24), cyclomorusin (30), and kuwanon C (33), isolated by our group is lay in the mode of attachment of the C5 unit to ring A. 

Morusin (3), a flavone derivative, isolated from the root bark of Morus alba L., as a main isoprenylated flavonoid, has a structure bearing an isoprenoid moiety at the C-3 position and a 2, 4 -dioxygenated pattern in the B ring [15]. These features are one of the characteristics of the isoprenylated flavonoids of Morus root bark. 

F g- (4). Isolation procedure of flavonoids from the root bark of Morus alba. 

Morus alba (mulberry) (Moraceae) [root bark] Morus alba (mulberry) (Moraceae) [root bark] Animals - endogenous Bombesin family peptide... 

The fhiits, leaves, and root bark of white mulberry trees Morus alba-, Moraceae) have yielded many polyhydroxy pyrrolidines and piperidines,especially DNJ and its glycosides. One unusual alkaloid is the Ai-propionamide derivative of (2if,3if,4if)-2-hydroxymethyl-3,4-dihydroxypyrrolidine (13) or its enantiomer. ... 

Crude drug. Mori cortex, dried root bark of Morus alba L, of the Japanese Pharmacopoeia XII quality was purchased form to Tochimoto Co., Ltd. (Japan) in 1994 and identified by Dr. N. Ishizaka, Professor of the department of Biology in Hokkaido College of Pharmacy, Japan. 

Yamatake, Y., M. Shibata, and M. Nagai Pharmacological Studies on Root Bark of the Mulberry Tree Morus alba L.). Japan J. Pharmacol. 26, 461 (1976). 

Nomura T, Fukai T 1980 Kuwanon G, a new flavone derivative from the root bark of the cultivated mulberry tree (Morus alba L.) Chem Pharm Bull 28 2548-2552... 

Magnolia acuminata extract Mulberry (Morus bombycis) extract botanical, body treatments Willow (Salix alba) bark extract botanical, body washes Willow (Salix aiba) bark extract botanicai, bubbie baths Orris root extract botanicai, cieansers... 

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