Morus root bark

Hano, Y. and Nomura T., Constituents of the Chinese crude drug Sang-bai-pi Morus root barks), IV. Structures of four new flavonoids, Sanggenon H, I, J and K, Heterocycles, 20, 1971, 1983. 

Fukai, T. et al.. Structure of sanggenon G, a new Diels-Alder adduct from Chinese crude drug Sang-Bai-Pi Morus root bark). Heterocycles, 20, 611, 1983. 

Morusin (3), a flavone derivative, isolated from the root bark of Morus alba L., as a main isoprenylated flavonoid, has a structure bearing an isoprenoid moiety at the C-3 position and a 2, 4 -dioxygenated pattern in the B ring [15]. These features are one of the characteristics of the isoprenylated flavonoids of Morus root bark. 

Figure 5 Typical Diels AIder type adducts from Morus root bark...

Studies of the phenolic constituents of Morus root bark were originally undertaken to characterize the hypotensive components of the root bark. Kuwanons G (25) (33), H (26) (34), M (160) (136), mulber-rofurans C (130) (111), F (131) (112), and G (27) (112) were shown to be hypotensive components of the root bark of the cultivated mulberry tree. Compounds 25, 26, 130, 131 and 27 were almost equally effective in causing a transient decrease in arterial blood pressure in doses of 0.1-1 mg/Kg (i.v.) in rabbits. Kuwanon M (160) (136) showed hypotensive action in hypertensive rats (2 mg/Kg, i.v,). On the other hand, sanggenons C (164) (140) and D (165) (141) were characterized as the hypotensive compounds of the crude medicine Sang-Bai-Pi . Sanggenon C (164) showed a marked hypotensive effect (1 mg/Kg, i.v.) in rabbits, and 165 showed the same effect (0.5-2.0 mg/Kg, i.v.) in rats. The mechanism of the hypotensive action of 25 and 26 has been discussed (95). 

Antimicrobial activities of some flavonoids with isoprenoid substituents and Diels-Alder type adducts obtained from Morus root bark were also studied. All of the tested compounds were effective against gram-positive bacteria and against some species of fungi, whereas they were inactive against gram-negative bacteria, as shown in Table 11. 

Formation of some products from [1 — " C] arachidonic acid was studied in rat platelets in the presence of phenolic compounds isolated from the Morus root bark. Morusin (24) was found to inhibit the formation of 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT) and thromboxane B2 (cyclooxygenase products) more strongly than the formation of 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) (12-lipoxygenase product). Oxydihydromorusin (34) and kuwanon C (33) were also found to inhibit the formation of thromboxane B2 more... 

Tanemura, I. Studies on the Hypotensive Constituents of Morus Root Bark. Nihon Yakurigaku Zasshi (Folia Pharmacol. Japan) 56, 704 (1960). 

OsHiMA, Y., C. Konno, H. Hikino, and K. Matsushita Structure of Moracenin C, a Hypotensive Principle of Morus Root Barks. Heterocycles 14,1461 (1980). 

Hano, Y., T. Fukai, H. Tsubura, and T. Nomura Some Pigments and Related Compounds of Morus Root Bark, 27th Symposium on the Chemistry of Natural Products, Abstract Paper, p 710, Oct. Hiroshima, Japan, 1985. 

Nomura, T., T. Fukai, and Y. Hano Constituents of the Cultivated Mulberry Tree IX. Constituents of the Chinese Crude Drug Sang-Bai-Pi Morus Root Bark) I. Structure of a New Flavanone Derivative, Sanggenon A, Planta medica 47, 30 (1983). 

Sun, J.-Y., J.-Y. Lou, S. Suzuki, Y. Hano, and T. Nomura On the Components of the Chinese Morus Root Bark. 2., 34th Annual Meeting of the Japanese Society of Pharmacognosy, Abstract Papers, p 155, Oct., 1987, Osaka, Japan. 

Fukai, T., Y. Hano, T. Fujimoto, and T. Nomura Structure of Sanggenon G, a New Diels-Alder Adduct from the Chinese Crude Drug Sang-Bai-Pi Morus Root Barks). Heterocycles 20, 611 (1983). 

Nomura T, Fukai T, Hano Y, Uzawa J 1981 Structure of sanggenon C, a natural hypotensive Diels-Alder adduct from Chinese crude drug sang-bai-pi (morus root barks). Heterocycles 16 2141-2148... 

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