Chemistry and pharmacological activity

The genus Aristolochia comprises approximately 200 species, many of which have played important roles in folk medicine for treating sore throat, venomous snakebites, wounds, fevers, and tuberculosis. The chemistry and pharmacology of aristolochic acid, the main active principle, was researched by many scientists. Many worthy achievements in the pharmacology of aristolochic acid have been published. 

Comprehensive reviews of the chemistry of sydnones (1) have been published elsewhere, and a general discussion of this subject is not included here. Recent work on the photochemistry (Section IX), physical and theoretical studies (Section XI), and pharmacological activity (Section XII) of sydnones (1) is included in later sections. 

Tundis R, Loizzo MR, Menichini F, Statti GA, Menichini F. Biological and Pharmacological Activities of Iridoids Recent Developments. Mini-Reviews in Medicinal Chemistry 2008 8 399-420. 

Willuhn, G. 1998. Arnica flowers pharmacology, toxicology and anlysis of the sesuiterpene lactonesn, their main active substance. In Lawsib, L. D. and R. Bauer (eds.). Phytomedicines of Europe, Chemistry and Biological Activity. American Chemical Society. Washington, D.C. p. 118-132. 

Gribble GW (1990) Synthesis and antitumour activity of ellipticine alkaloids and related compounds. The Alkaloids, Chemistry and Pharmacology (ed Brossi A) Vol 39. Academic, San Diego, pp 239-352. 

NAPRALERT (NAtural PRoducts ALERT) contains bibliographic and factual data on natural products, including information on the pharmacology, biological activity, taxonomic distribution, ethnomedicine and chemistry of plant, microbial, and animal (including marine) extracts, and data on the chemistry and pharmacology of secondary metabolites that are derived from natural sources. It is produced by the University of Illinois School of Pharmacy and covers 1650 to date. 

CasyAF. Chemistry and structure-activity relationship of synthetic anti-hista-mines. In Histamine and anti-Histami-nics. II, Handbook of Experimental Pharmacology. Rocha e Silva M (Ed.). Springer, Berlin, 1978, p. 175. 

Very recently some light has been shed on the chemistry of raujemi-dine (42) which at one time seemed to be the only naturally occurring and pharmacologically active stereoisomer of reserpine (130). Raujemi-dine has now been shown to be an unsaturated derivative of reserpine, viz., the J19,20 compound (133a). Upon comparing reserpine with raujemidine, a certain similarity in the space distribution pattern (viz., bulkiness to the right of the basic nitrogen and above the plane of the... 

APPLICATIONS IN PHARMACY, PHARMACEUTICAL CHEMISTRY AND PHARMACOLOGY Possible applications and recent developments Polarographic activity of pharmaceuticals... 

Subsequent to the appearance of Volume VI of this series, a number of reviews on the tropane alkaloids have appeared, dealing with chemistry (i, 2), biosynthesis and biogenesis (3, 4), and pharmacological activity as a function of structure (5, 6). 

An efficient, highly regioselective, synthesis of fluoro amino acids could have particular significance in medicinal chemistry and pharmacology, because of the increasing interest in the incorporation of fluoro amino acids into physiologically active peptides. 

Voacanga africana Chemistry, Quality and Pharmacological Activity... 

Furthermore, the chiral discrimination of monoterpenes has been recognized as one of the most important analytical techniques in flavor chemistry and pharmacology because the optically active stereoisomers have different sensory qualities and biological activities. HPLC offers powerful techniques for separation and quantification of enantiomers because of the progressive improvement of chiral chromatographic materials and chiral detectors such as optical rotatory dispersion (ORD) and circular dichroism (CD) detectors. In contrast, determination of chiral compounds by GC typically requires coinjection of the reference compound with known stereochemistry. An HPLC system equipped with a chiral detector, on the other hand, allows direct determination of the configuration of chiral compounds.84... 

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