Voacanga africana

The enzyme responsible for the stereospecific condensation of trypt-amine and secologanin 34) was called strictosidine synthase, and its presence was demonstrated by Treimer and Zenk 194) in a number of indole alkaloid-producing plants, including Amsonia salicifolia, Catharanthus roseus, Ochrosia elliptica, Rauwolfia vomitoria, Rhazya orientalis, Stem-madenia tomentosa. Vinca minor, and Voacanga africana. Enzyme activity as high as 1698 pkat/mg protein was observed for O. elliptica. No... 

Tabersonine Catharanthus ovalis Stemmademia tomentosum Voacanga africana... 

Ehiabhi, O.S., Edet, U.U., Walker, T.M., Schmidt, J.M., Setzer, W.N., Ogunwande, I.A., Essien, E. and Ekundayo, O. (2003) Constituents of essential oils of Apium graveolens L., Allium cepa L., and Voacanga africana Staph, from Nigeria. Journal of Essential Oil Bearing Plants 9(2), 126-132. 

Isolation of the stereospecific strictosidine s)mthase (STS) and formation of strictosidine with the 3a-(S) configuration proved conclusively that this was the natural precursor of the terpenoid indole alkaloids. Strictosidine occurs naturally in Rhazya stricta and the synthase has been isolated from a number of other species Amsonia salicifolia, A. tabemaemontam, Catharanthus pusillus, C. roseus, Rauvolfia verticillata, R. vomitoria, R. serpentina, Rhazya orientalis and Voacanga africana. The enzyme has been purified to homogeneity from R. serpentina (Hampp and Zenk, 1988). A comparison of the activity of STS from C. roseus roots, the only portion of the plant to contain ajmalicine, with that present in plant cell cultures producing the same alkaloid demonstrated that the plant cell cultures are far more metabolically active (Ziegler and Facchini, 2008). 

Voacanga africana Stapf. Bulen Giddiness (St) Water maceration... 

Voacanga africana Chemistry, Quality and Pharmacological Activity... 

Table L Color, Moisture, Total Ashes and Acid Insoluble Ashes of Voacanga africana from Ghana...

Table II - Percentage of Seed Clusters, Whole, Broken Seeds, Density and Alkaloid Content from Voacanga africana...

Table III. Proposed Quality Control Standards for Voacanga africana Seeds...

Source Voacanga africana. Molecular formula C22H28 N2O4. Biological activity Analgesic. 

A pentacyclic alkaloid, so far unnamed, isolated (90) from the leaves of Voacanga africana Stapf, is the epoxide 75 of a degraded aspidospermane base in which C-5 and C-6 of the original tryptamine ethanamine chain have been lost this is the first recorded occurrence of this ring system. 

Demethoxycarbonylvoacamine (158), Voacamine-A(b)-oxide (159), and Voaca-midine (145).— Voacamine (141), on hydrolysis of the two ester functions followed by heating with methanolic hydrochloric acid, gives only 18 -demethoxycarbonyl-16-epivoacamine. The actual 18 -demethoxycarbonylvoacamine (158) was obtained by partial synthesis from vobasinol (144) and ibogaine (160). It occurs naturally in Voacanga africana Stapf. ... 

A number of new alkaloids are closely related to vobtusine. These include vobtusine lactone (alkaloid V) and desoxyvobtusine lactone (alkaloid IV) from Voacanga africana Stapf. and desoxyvobtusine, voafoline (alkaloid VII), isovoafoline, voafolidine (alkaloid IX), and folicangine (alkaloid VIII) from the same plant. From Callichilia (Hedranthera) barteri (Hook.f.) Pichon owerreine, goziline (= desoxyvobtusine ), and amataine have been isolated. 

Goziline (= desoxyvobtusine ) (267). Although a direct comparison is lacking, it would appear that goziline from Callichilia barteri and desoxyvobtusine from Voacanga africana are either identical or stereoisomeric with each other. 

Details720 have been published of the isolation and spectral properties of iso-voafoline, voafoline, voafolidine, and folicangine from Voacanga africana the... 

Numerous alkaloids have been isolated from Voacanga africana Stapf., and Poisson and co-workers (85) have reported on two new compounds having the quebrachamine skeleton. 

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