Alkaloids ellipticine

In 1981, Potier et al. reported the isolation of N-oxyellipticine (240) from O. moorei (181). In the following year, Michel et al. reported the isolation of another N-oxyellipticine derivative, N-oxy-13-oxoellipticine (241), from the stem bark of S. dinklagei (184). Five years later, the same authors isolated from the bark of the same natural source, a novel, natural, bis-ellipticine alkaloid, strellidimine (242), in racemic form (221). Strellidimine represented the first example of a natural bis-ellipticine alkaloid, containing a 9-hydroxyellipticine (230) unit (see Scheme 2.56) linked to a 3,4-dihydroellipticine (236) unit (see Scheme 2.57) (221) (Scheme 2.59). 

Gribble GW (1990) Synthesis and antitumour activity of ellipticine alkaloids and related compounds. The Alkaloids, Chemistry and Pharmacology (ed Brossi A) Vol 39. Academic, San Diego, pp 239-352. 

SYNTHESIS AND ANTITUMOR ACTIVITY OF ELLIPTICINE ALKALOIDS AND RELATED COMPOUNDS... 

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