Chemical Synthesis Multicomponent

Key words Chemical space, Multicomponent reactions. Biology-oriented synthesis. Diversity-oriented synthesis. Divergent selectivity... 

Multicomponent diffusion The mathematical description of diffusion of more than one component is a complex problem and not germane to our subject. However, with the present trend toward increasing use of solid catalysts in chemical synthesis, many situations do arise in which multicomponent diffusion is involved. We left the prediction of the multicomponent diffusivity outside the scope of this book, which can be found elsewhere (Doraiswamy, 2001). Once the multicomponent diffusivity is determined, the effective diffusivity can then be found from Equation 6.7. 

Tietze, L.F. 8c Modi, A. (2000) Multicomponent Domino Reactions for the Synthesis of Biologically Active Natural Products and Drugs. Medical Chemical Reviews, 20, 304-322. 

Dondoni, A. Massi, A. (2006) Design and Synthesis of New Classes of Heterocyclic C-Glycoconjugates and Carbon-Linked Sugar and Heterocyclic Amino Acids by Asymmetric Multicomponent Reactions (AMCRs). Accounts of Chemical Research, 39, 451M63. 

Acke DRJ, Orru RVA, Stevens CV (2006) Continuous synthesis of tri- and tetra-substituted imidazoles via a multicomponent reaction under microreactor conditions. QSAR Comb Sci 25 474-483 Antes J, Tuercke T, Marioth E, Lechner F, Scholz M, Schntirer F, Krause HH, Lobbecke S (2001) In Matlosz M, Ehrfeld W, Baselt JP (eds) IMRET 5 Proceedings of the Fifth International Conference on Microreaction Technology. Springer Berlin New York Heidelberg, pp 446 153 Barrow D, Cefai J, Taylor S (1999) Shrinking to fit. Chem Ind 15 591-594 Bradley D (1999) Chemical Reduction. Eur Chem 1 17-20 Chambers RD, Spink RCH (1999) Microreactors for Elemental Flourine. Chem Comm 10 883-884... 

Jean Rodriguez was born in Gieza, Spain, on 25 June 1958, and in 1959 his family emigrated to France. After studying chemistry at the University Paul Cezanne in Marseille, France, he completed his PhD as a CNRS student with Prof. B. Waegell and Prof. P. Brun in 1987. He completed his Habilitation in 1992, also at Marseille, where he is currently Professor and Director of the UMR-CNRS-6178-SYMBIO. His research interests include the development of domino and multicomponent reactions, and their applications in stereoselective synthesis. In 1998, he was awarded the Acros prize in Organic Chemistry from the French Chemical Society. 

Abstract Piperazines and its congeners, (di)keto piperazines are valuable tools in drug discovery, providing a natural path for the process peptide > peptidomimetic > small molecule also called depeptisation. Moreover, they can provide molecular probes to understand molecular pathways for diseases of unmet medical need. However, in order to better understand the design of such value added compounds, the detailed understanding of scope and limitation of their synthesis as well as their 3D structures and associated physicochemical properties is indispensables. Isocyanide multicomponent reaction (MCR) chemistry provides a prime tool for entering the chemical space of (di)(keto)piperazines since not less then 20 different ways exist to access a diversity of related scaffolds. 

Hur et al. (252,277,278) reported the use of alkali metal-doped MgO to catalyze the synthesis of acrylonitrile and propionitrile (278). Acrylonitrile is an important chemical, especially in the polymer industry it is generally synthesized by the ammoxidation of propene catalyzed by multicomponent bismuth molybdates (279). An alternative method of synthesis of acrylonitrile is the reaction between methanol and acetonitrile (Scheme 42). 

There are many excellent texts on combustion [153,235,380,412,424,435], all of which discuss fundamental principles but differ in their applications focus. The classic book by Bird, Stewart, and Lightfoot emphasizes the fundamental principles of transport phenomena, including multicomponent and chemically reacting flow [35]. Rosner s book [339] also develops much of the transport theory for chemically reacting flow systems. In materials processing, such as the synthesis of electronic thin films, there are fewer texts that present the details of chemically reacting flow. However, excellent presentation of the fundamentals can be found in book chapters by Kleijn [228] and Jensen [202]. 

S. H. Cheng and Y. A. Liu. Studies in chemical process design and synthesis 8. A simple heuristic method for systematic synthesis of initial sequences for sloppy multicomponent separations. I ECRes., 27 2304, 1988. 

Raffaella Ocone and Gianni Astarita, Kinetics and Thermodynamics in Multicomponent Mixtures Arvind Varma, Alexander S. Rogachev, Alexandra S. Mukasyan, and Stephen Hwang, Combustion Synthesis of Advanced Materials Principles and Applications J. A. M. Kuipers and W. P. Mo, van Swaaij, Computional Fluid Dynamics Applied to Chemical Reaction Engineering... 

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