Chemical prioritization

Industrial Chemical Prioritization and Determination of Critical Hazards of Concern. Technical Annex and Supporting Documents for International Task Force (IIF)40, Industrial Chemical Hazards Medical and Operational Concerns. UASCHPPM Report 47-EM-6154-03. US Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, MD, 2003. 

Prioritization of chemicals Prioritization of site cleanup or prevention... 

Rabinowitz, J. R., Goldsmith, M. R., Little, S. B., and Pasquinelli, M. A. (2(X)8). Computational molecular modeling for evaluating the toxicity of environmental chemicals Prioritizing bioassay requirements. Environ Health Perspect 116, 573-577. 

Organization for HAZMAT Emergencies Part 1 Hazards Analysis Uses case studies to explain hazard identification, vulnerability analysis, risk assessment toxicity, flammability, and reactivity of chemicals prioritizing hazards and how vapor plumes are affected by weather and chemical composition. 

The Scorecard Database provides information on chemical releases, risk prioritization of substances and other relevant information for chemicals and facilities. 

The analysis methods are national in scope and address emissions from a wide variety of industrial and community source types. The materials reviewed are of widely disparate natures. They include metals, and bulk and trace hydrocarbons, including chlorinated and oxide derivatives of hydrocarbons. The analyses are intended to be preliminary screening analyses for use in scoping and prioritizing regulatory attention to toxic exposures from the chemicals studied. 

Risk assessment constitutes a cornerstone for the control of chemicals for both scientific and management purposes. Environmental risk management deals with regulatory measures based on risk assessment [3], Strategies such as the prioritization of chemicals represent a useful tool to optimize efforts for both regulatory and monitoring purposes [4, 5]. 

Judson R, Houck K, Kavlock RJ, Knudsen T, Martin T, Mortensen HM, Reif D, Rotroff D, Shaha I, Richard AM, Dix DJ (2010) In vitro screening of environmental chemicals for targeted testing prioritization the ToxCast project. Environ Health Perspect 118 485-492... 

If several processes require PrHAs, the PrHAs must be prioritized. A preliminary hazard analysis (PHA) may be used to determine and document the priority order for conducting PrHAs. At a minimum, the PSM Rule requires the prioritization to consider the potential severity of a chemical release, the number of potentially affected employees, and the operating history of the process, including the frequency of past chemical releases and the age of the process. 

Chemical Exposure Index (CEI) (Chemical Exposure Index, 1994 Mannan, 2005, pp. 8/22-8/26.) The CEI provides a method of rating the relative potential of acute health hazard to people from possible chemical release incidents. It may be used for prioritizing initial process hazard analysis and establishing the degree of further analysis needed. The CEI also may be used as part of the site review process. The system provides a method of ranking one risk relative to another. It is not intended to define a particular containment system as safe or unsafe, but provides a way of comparing toxic hazards. It deals with acute, not chronic, releases. Flammability and explosion hazards are not included in this index. To develop a CEI, information needs include... 

The idea of prioritizing those substances which will be tested is not new. Every organization that has to consider the testing or assessment of chemicals has to prioritize its efforts. Some have done it formally and others informally. The U.S. EPA Interagency Testing Committee (ITC) has developed a procedure... 

The ACS GCI Pharmaceutical Roundtable recently set out to prioritize the areas of chemical synthesis where unproved methodology would realize the greatest beneficial impact on pharmaceutical production. This resulted in the publication of a wish list of currently utilized transformations that require better reagents and aspirational transformations that would provide shorter routes were they available (Table 1.3). ... 

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