Chem Robot

An open source-based computer program called Chem Robot is developed which can use digital video devices to capture and analyze rapidly hand-drawn or computer- 

1 Open-Source Tools, Techniques, and Data in Chemoinformatics 

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J. P. Whitten, Y. E Xie, P. E. Erickson, T. R. Webb, E. B. De Souza, D. E. Grigoriadis, J. R. McCarthy, Rapid Microscale Synthesis, a New Method for Lead Optimization Using Robotics and Solution Phase Chemistry Application to the Synthesis and Optimization of Corticotropin-Releasing Factor Receptor Antagonists , J. Med. Chem. 1996,39, 4354-4357. 

Corey has discussed the similarities and differences between synthetic and biological catalysts, coined the term chemzymes for the former, and discussed the connections between these microscopic catalysts and macroscopic robots. See Corey, E J. New Enantiose-lective Routes to Biologically Interesting Compounds Pure Appl. Chem 1990, 62,1209-1216. 

Rojas R, Harris NK, Piotrowska K, Kohn J (2009) Evaluation of automated synthesis for chain and step-growth polymerizations can robots replace the chemists J Poly Sd Part A Polym Chem 47 48-58... 

Lim CK, Peters TJ (1984) Urine and faecal porphyrin profiles by reversed-phase high-performance liquid chromatography in the porphyrias. Clin Chim Acta 139 55-63 Minder El, Vuilleumier JP, Vonderschmitt DJ (1992) Prototype application of robot in the clinical laboratory enabling fully automated quantification of fecal porphyrins. Clin Chem 38 516-521... 

Zahradnik, P. and Swietly, H., The robotized chemical treatment of diluted spent fuel samples prior to isotope dilution analysis, J. Radioanal. Nucl. Chem., 204, 145-157, 1996. 

Houthaeve, T. Gausepohl, H. Ashman, K. Nillson, T. Mann, M. 1997. Automated protein preparation techniques using a digest robot. J. Protein Chem., 16,343-348. 

Whitten JP, Yon Feng Xie, Erickson PE, Webb TR, De Souza EB, Grigariadis DE, McCarthy JR, Rapid microscale synthesis, a new method for lead optimization using robotics and solution phase chemistry application to the synthesis and optimization of corticotropin-releasing factor, receptor antagonists, J. Med. Chem., 39 4354-4357, 1996. 

Cargill, J. E. and Lebl, M. (1997) New methods in combinatorial chemistry Robotics and parallel synthesis. Curr. Opin. Chem. Biol. 1, 67-71. 

Automated Environmental Lab Combines Robotics , Chem. d Eng. News, 14 Aug. (1996). 

J.M. Onorato, J.D. Henion, P.M. Lefebvre, J.P. Kiplinger, SRM LC-MS determination of idoxifene and its pyrrolidinone metabolite in human plasma using robotic high-throughput, sequential sample injection. Anal. Chem., 73 (2001) 119. 

Figure 11 -7 Workstations with clusters of tike Instruments (e.g., chemistry analyzers, Chem I through Chem 4, or hematology analyzers, Heme 1 through Heme 4) enable one technologist to operate and monitor the functions of several analyzers simultaneously. The central control module is usually provided by the manufacturer of the analyzers in each duster. (From Boyd JC, Felder RA, Savory j. Robotics and the changing face of the clinical laboratory. Clin Chem 1996 42 1901-10.)...

Boyd JC, Felder RA, Savory J. Robotics and the changing face of the clinical laboratory. Clin Chem 1996 42 1901-10. 

Felder RA, Boyd JC, Margrey K, Holman W, Savory J. Robotics in the medical laboratory. Clin Chem 1990 36 1-310. 

Margrey KS, Martinez A, Vaughn DP, Felder RA. A standard clinical instrument interface for robotic applications, Clin Chem 1990 36 1572-5. 

Morgenstern S, Kessler G, Auerbach J, Flor RV, Klein B. An automated p-nitrophenylphosphate serum alkaline phosphatase procedure for the "Robot Chemist . Clin Chem 1965 11 889-97. 

For a description of laboratory robots, see G.J. Kost, Ed., Handbook of Clinical Automaliun, Robotics and Optimization. New York Wiley, 1996 J. R. Strimaltis and G. L. Hawk. Advances in Laboratory Automation-Robotics. Hopkinton. MA Zymark Corp. 1998 V. Berry. Anal. Chem.. 1990, 62, 331A J. R. Strimaltis, J. Cheni. Educ.. 1989, 66, A8 1990, 67, A20 W. J. Hurst and J. W. Mortimer, Laboratory Robotics. New York VCH Publishers, 1987. 

JA Boutin, P Hennig, PH Lambert, S Bertin, L Petit, JP Mahieu, B Serkiz, JP Volland, JL Fauchere. Combinatorial peptide libraries robotic synthesis and analysis by nuclear magnetic resonance, mass spectrometry, tandem mass spectrometry, and high-performance capillary electrophoresis techniques. Anal Bio-chem 234 126-141, 1996. 

Onorato, J.M. Henion, J.D. Lefebvre, P.M. Kiplinger, J.P. Selected Reaction Monitoring LC-MS Determination of Idoxifene and Its Pyrrolidinone Metabolite in Human Plasma Using Robotic High-Throughput, Sequential Sample Injection, Anal. Chem. 73, 119-125 (2001). 

Harris, C.M. Finding the Right Robot for MALDI, Anal. Chem. 73( 15), 447A-451A (2001). 

JF Cargill, M Lebl. New methods in combinatorial chemistry—robotics and parallel synthesis. Curr Opin Chem Biol 1 67-71, 1997. 

H.M. Kingston, M.L. Kingston, Nomenclature in laboratory robotics and automation (IUPAC recommendations 1994), J. Autom. Chem. 16 (1994) 43. 

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