Chelating agents inhibition

The apo-carbonic anhydrase, as well as other manganese-chelating agents, inhibit this epoxidation. Adding apo-carbonic anhydrase to a manganese-catalyzed epoxidation of 4-vinylbenzoic acid inhibited the reaction [46]. This observation is consistent with the binding of free manganese by the apo-enzyme and a slower epoxidation... 

Addition of chelating agents to the fermentation medium may help to inhibit phage multiplication by prevention of phage adsorption to the cell wall. 

Microtubules can be reconstituted in vitro at 37 °C from a solution that contains a physiological mixture of brain tubulin, MAPs, small amounts of guanosine 5 -triphosphate (GTP), magnesium ions, and the calcium-chelating agent EGTA [ethylene glycol-bis(2-aminoethyl ether) N, N -tetraacetic acid]. Tubulin assembly is inhibited by low temperature and by the presence of calcium ions. 

Figure 12-7. Proposed sites of inhibition (0) of the respiratory chain by specific drugs, chemicals, and antibiotics. The sites that appear to support phosphorylation are indicated. BAL, dimercaprol. TTFA, an Fe-chelating agent. Complex I, NADHiubiquinone oxidoreductase complex II, succinate ubiquinone oxidoreductase complex III, ubiquinohferricytochrome c oxidoreductase complex IV, ferrocytochrome ctoxygen oxidoreductase. Other abbreviations as in Figure 12-4.

Thennodynamic inhibitors are complexing and chelating agents, suitable for specific scales. For example, for scale inhibition of barium sulfate, common chemicals are ethylenediaminetetraacetic acid (EDTA) andnitrilotriacetic acid. The solubility of calcium carbonate can be influenced by varying the pH or the partial pressure of carbon dioxide (CO2). The solubility increases with decreasing pH and increasing partial pressure of CO2, and it decreases with temperature. 

Bowern, N., Ramshaw, LA., Clark, LA. and Doherty, P.C. (1984). Inhibition of autoimmune neuropathological process by treatment with an iron-chelating agent. J. Exp. Med. 160, 1532-1543. 

Arsenic uptake in rabbit intestine is inhibited by phosphate, casein, and various metal-chelating agents (USEPA 1980). Mice and rabbits are significantly protected against sodium arsenite intoxication by (V-(2,3-dimercaptopropyl)phthalamidic acid (Stine et al. 1984). Conversely, the toxic effects of arsenite are potentiated by excess dithiols, cadmium, and lead, as evidenced by reduced food efficiency and disrupted blood chemistry in rodents (Pershagen and Vahter 1979). 

Dopamine-j3-oxidase contains copper and is inhibited [343] by copper-chelating agents such as 2,9-dimethyl-o-phenanthroline (XCV). The aminoguanidine... 

This enzyme [EC 3.4.13.3] (also referred to as Xaa-His dipeptidase, X-His dipeptidase, aminoacylhistidine dipeptidase, and homocarnosinase), is a zinc-dependent dipeptidase that catalyzes the hydrolysis of Xaa-His dipeptides. Carnosine, homocarnosine, and anserine are preferred substrates for this mammalian cytosolic enzyme. Other aminoacylhistidine dipeptides are weaker substrates (including homoanserine). The enzyme is activated by thiols and inhibited by metal-chelating agents. O. W. Griffith (1986) Ann. Rev. Biochem. 55, 855. 

Other compounds that have been tested for their inhibiting action include carboxylic acids, hydrazine hydrate, chelating compounds, aniline and related compounds and petroleum-based compounds. The influence of various chelating agents such as TEA, EDTA, DPTA, HEDTA and Chel-138 on their ability to control corrosion has been investigated [70]. All the chemicals are reported to reduce the compressive strength of concrete. The strengths were particularly low in the presence of TEA and EDTA, compared to the reference. In the presence of 0.1 N NaCl solution at pH 10... 

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