Copper chelating agents

Dopamine-j3-oxidase contains copper and is inhibited [343] by copper-chelating agents such as 2,9-dimethyl-o-phenanthroline (XCV). The aminoguanidine... 

Treat fuel with a copper chelating agent or a metal deactivator. 

No color in any tubes Sample contains copper chelating agent Dialyze or dilute the sample... 

Triethylene tetramine The copper-chelating agent triethylene tetramine (trientine) can be considered as an alternative therapy to penicillamine (J.M. Walshe, 1982). (389) The initial dose is 3-4 x 600 mg/day the recommended maintenance dose is 2 x 600 mg/day, administered about one hour before meals. The side effects are similar to those observed with penicillamine, but effi-... 

Metal Deactivator S. [Hart Chem. Ltd.] N,N -Disa]icylidene-1,2-propane diamine copper chelating agent for refinery industry. 

T rientine is a copper chelating agent used for Wilson s disease. One of the adverse effects of trientine is that it can cause iron deficiency, probably because it chelates with iron in the gut and thereby reduces its absorption. It is usual to make good this iron defieieney where necessary by giving an iron supplement. The manufaeturers suggest that the iron supplement should he given at a different time of the day from trientine to minimise their admixture in the gut. - A separation of at least 2 hours is recommended. ... 

Sodium diethyldithiocarbamate inhibits prostaglandin synthetase at 10 (ig/ml. The site of action is not at the fatty acid substrate site. It is a copper chelating agent and probably prevents the interaction of oxygen with the enzyme. 

The enlargement of the mitochondrial compartment in male Wistar rats placed on a copper-deficient diet at 10 days of age (Dallman and Goodman 1970) is related to the depletion of cytochromes and in activity of cytochrome oxidase (Dallman 1967). By feeding weanling mice the copper-chelating agent, cuprizone, Tandler and Hoppel (1972) considerably enhanced the number of cardiac mitochondria and the frequency of occurrence of partitioned mitochondria. 

As described previously, the ratio of copper to cytochrome a is always 1 and the oxidase activity is inhibited about 50% by the addition of a copper chelating agent. From the above results, it is certain that the copper in cytochrome a as well as the heme iron is an important component in the oxidase reaction. Recently it was shown that the copper in oxidized cytochrome a is in the cupric state and that it changes in valency together with the iron during electron transfer from substrate to oxygen. 

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